Equine YKL-40 antibody and antigen (recombinant protein)

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-EQU-YKL-40-Ag01	Recombinant Equine YKL-40 protein	3090
GMP-EQU-YKL-40-Ab01	Anti-Equine YKL-40 mouse monoclonal antibody (mAb)	1953
GMP-EQU-YKL-40-Ab02	Anti-Equine YKL-40 mouse monoclonal antibody (mAb)	1953
GMP-EQU-YKL-40-Ab03	Anti-Equine YKL-40 human monoclonal antibody (mAb)	1953
GMP-EQU-YKL-40-Ab04	Anti-Equine YKL-40 human monoclonal antibody (mAb)	1953

Size： 1mg | 10mg | 100mg

Product Description

Cat No. of Products	GMP-EQU-YKL-40-Ag01
Product Name	Recombinant Equine YKL-40 protein
Target/Biomarker	Equine Chitinase-3-like protein 1 (YKL-40)
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Equine Chitinase-3-like protein 1 antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in YKL-40 level test of animal Equine/Horse with Alzheimer Disease(AD).
Tag	His
Products description	Recombinant Equine YKL-40 protein was expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-EQU-YKL-40-Ab01, GMP-EQU-YKL-40-Ab02
Product Name	Anti-Equine YKL-40 mouse monoclonal antibody (mAb)
Target/Biomarker	Equine Chitinase-3-like protein 1 (YKL-40)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Equine Chitinase-3-like protein 1 antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-YKL-40 antibodies in YKL-40 level test of animal Equine/Horse with Alzheimer Disease(AD).
Tag	mFc
Products description	Anti-Equine YKL-40 mouse monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-YKL-40 antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-EQU-YKL-40-Ab03, GMP-EQU-YKL-40-Ab04
Product Name	Anti-Equine YKL-40 human monoclonal antibody (mAb)
Target/Biomarker	Equine Chitinase-3-like protein 1 (YKL-40)
Expression platform	CHO
Isotypes	Human IgG1
Bioactivity validation	Recombinant Equine Chitinase-3-like protein 1 antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-YKL-40 antibodies in YKL-40 level test of animal Equine/Horse with Alzheimer Disease(AD).
Tag	hFc
Products description	Anti-Equine YKL-40 human monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-YKL-40 antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Target/Biomarker information

Equine YKL-40, a glycoprotein with a molecular weight of approximately 40 kDa, emerges as a captivating figure in the intricate realm of equine immune responses and tissue dynamics. While it bears structural resemblance to chitinases, it distinguishes itself by its absence of chitinase activity. Its presence is pervasive in various equine tissues, with prominent expression in the liver, kidneys, lungs, and immune cells. Structurally, Equine YKL-40 is characterized by its unique chitin-binding domain, which suggests involvement in tissue remodeling and repair. The glycosylation of this protein enhances its stability and modulates its functions, particularly within the context of inflammation. The regulation of Equine YKL-40 expression is tightly orchestrated, with immune cells, including macrophages and neutrophils, being significant contributors. These cells are activated in response to inflammatory cues, prompting YKL-40 production. This induction underscores its role as a pro-inflammatory mediator and a sentinel of immune system activation. Beyond its role in immune responses, Equine YKL-40 is intricately linked to tissue remodeling processes. In conditions characterized by tissue injury and repair, such as wound healing and fibrosis, YKL-40's interactions with fibroblasts and epithelial cells gain prominence. It appears to modulate cellular activities associated with extracellular matrix turnover and tissue restructuring.

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