Equine VDBP antibody and antigen (recombinant protein)

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-EQU-VDBP-Ag01	Recombinant Equine VDBP protein	3090
GMP-EQU-VDBP-Ab01	Anti-Equine VDBP mouse monoclonal antibody (mAb)	1953
GMP-EQU-VDBP-Ab02	Anti-Equine VDBP mouse monoclonal antibody (mAb)	1953
GMP-EQU-VDBP-Ab03	Anti-Equine VDBP human monoclonal antibody (mAb)	1953
GMP-EQU-VDBP-Ab04	Anti-Equine VDBP human monoclonal antibody (mAb)	1953

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Product Description

Cat No. of Products	GMP-EQU-VDBP-Ag01
Product Name	Recombinant Equine VDBP protein
Target/Biomarker	Equine vitamin D binding protein (SPA)
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Equine vitamin D binding protein antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in SPA level test of animal Equine/Horse with liver failure, type I diabetes, cystic fibrosis.
Tag	His
Products description	Recombinant Equine VDBP protein was expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-EQU-VDBP-Ab01, GMP-EQU-VDBP-Ab02
Product Name	Anti-Equine VDBP mouse monoclonal antibody (mAb)
Target/Biomarker	Equine vitamin D binding protein (SPA)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Equine vitamin D binding protein antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-SPA antibodies in SPA level test of animal Equine/Horse with liver failure, type I diabetes, cystic fibrosis.
Tag	mFc
Products description	Anti-Equine VDBP mouse monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-SPA antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-EQU-VDBP-Ab03, GMP-EQU-VDBP-Ab04
Product Name	Anti-Equine VDBP human monoclonal antibody (mAb)
Target/Biomarker	Equine vitamin D binding protein (SPA)
Expression platform	CHO
Isotypes	Human IgG1
Bioactivity validation	Recombinant Equine vitamin D binding protein antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-SPA antibodies in SPA level test of animal Equine/Horse with liver failure, type I diabetes, cystic fibrosis.
Tag	hFc
Products description	Anti-Equine VDBP human monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-SPA antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Target/Biomarker information

Vitamin D-Binding Protein (VDBP) in horses, or equines, stands as a multifunctional molecular sentinel, bridging the realms of vitamin D metabolism and immune modulation within these majestic animals. Structurally, VDBP is a glycoprotein, weighing in at approximately 58-59 kDa, and it is synthesized predominantly in the liver before making its way into the bloodstream. Its foremost role in equine physiology revolves around the transportation of vitamin D metabolites, particularly vitamin D3. VDBP acts as a vigilant guardian, binding to vitamin D and ensuring its safe passage through the circulatory system. This chaperone-like function is of paramount importance, as it safeguards vitamin D from rapid degradation, enabling its efficient delivery to target tissues. Vitamin D, once delivered by VDBP, exerts its far-reaching effects, spanning from the regulation of calcium and phosphorus homeostasis, essential for bone health, to its role in modulating immune responses. In the context of vitamin D metabolism, VDBP acts as the linchpin, orchestrating the journey of vitamin D from its cutaneous or dietary sources to the cells and tissues that rely on it for proper functioning. Whether it's the intestinal absorption of calcium and phosphorus, the mineralization of bone, or the immune system's readiness to respond to challenges, VDBP ensures that vitamin D is where it needs to be when it's needed. But VDBP's influence transcends mere vitamin D transport. It wears a dual hat, engaging in immunomodulatory activities that underscore its significance in equine health. VDBP has the remarkable capacity to interact with the immune system, primarily through the activation of macrophages and dendritic cells. In doing so, it exerts a regulatory influence on immune responses, particularly those linked to infections and inflammation. In essence, VDBP connects the dots between vitamin D metabolism and immune functions in horses. It's not just a carrier protein; it's an active participant in the equine immune system. Its ability to modulate immune responses adds a layer of complexity to the understanding of how vitamin D, an essential nutrient, integrates with the immune defenses of these magnificent animals.

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