Equine TIMP-1 antibody and antigen (recombinant protein)

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-EQU-TIMP-1-Ag01	Recombinant Equine TIMP-1 protein	3090
GMP-EQU-TIMP-1-Ab01	Anti-Equine TIMP-1 mouse monoclonal antibody (mAb)	1953
GMP-EQU-TIMP-1-Ab02	Anti-Equine TIMP-1 mouse monoclonal antibody (mAb)	1953
GMP-EQU-TIMP-1-Ab03	Anti-Equine TIMP-1 human monoclonal antibody (mAb)	1953
GMP-EQU-TIMP-1-Ab04	Anti-Equine TIMP-1 human monoclonal antibody (mAb)	1953

Size： 1mg | 10mg | 100mg

Product Description

Cat No. of Products	GMP-EQU-TIMP-1-Ag01
Product Name	Recombinant Equine TIMP-1 protein
Target/Biomarker	Equine Matrix Metalloproteinase Inhibitor-1 (S100-A9)
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Equine Matrix Metalloproteinase Inhibitor-1 antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in S100-A9 level test of animal Equine/Horse with coronary artery stenosis, coronary artery lesions.
Tag	His
Products description	Recombinant Equine TIMP-1 protein was expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-EQU-TIMP-1-Ab01, GMP-EQU-TIMP-1-Ab02
Product Name	Anti-Equine TIMP-1 mouse monoclonal antibody (mAb)
Target/Biomarker	Equine Matrix Metalloproteinase Inhibitor-1 (S100-A9)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Equine Matrix Metalloproteinase Inhibitor-1 antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-S100-A9 antibodies in S100-A9 level test of animal Equine/Horse with coronary artery stenosis, coronary artery lesions.
Tag	mFc
Products description	Anti-Equine TIMP-1 mouse monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-S100-A9 antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-EQU-TIMP-1-Ab03, GMP-EQU-TIMP-1-Ab04
Product Name	Anti-Equine TIMP-1 human monoclonal antibody (mAb)
Target/Biomarker	Equine Matrix Metalloproteinase Inhibitor-1 (S100-A9)
Expression platform	CHO
Isotypes	Human IgG1
Bioactivity validation	Recombinant Equine Matrix Metalloproteinase Inhibitor-1 antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-S100-A9 antibodies in S100-A9 level test of animal Equine/Horse with coronary artery stenosis, coronary artery lesions.
Tag	hFc
Products description	Anti-Equine TIMP-1 human monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-S100-A9 antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

Click to get more Data / Case study about the product.

Target/Biomarker information

In horses, TIMP-1 demonstrates multifaceted functions beyond its role as a metalloproteinase inhibitor. Extensive research has revealed its involvement in various physiological and pathophysiological processes. TIMP-1 is secreted by different cell types, including fibroblasts, synovial cells, and chondrocytes, and its expression can be regulated by factors such as mechanical stress, growth factors, and cytokines. TIMP-1 modulates the balance between extracellular matrix components, such as collagen, elastin, and proteoglycans, by inhibiting the activity of matrix metalloproteinases. This regulation is critical for maintaining tissue homeostasis, preventing excessive matrix degradation, and promoting proper tissue repair. Furthermore, TIMP-1 has been implicated in angiogenesis, the process of forming new blood vessels. It influences endothelial cell migration, proliferation, and tube formation, all of which are indispensable for the formation of functional vasculature during wound healing and tissue regeneration in horses. Studies have also highlighted the role of TIMP-1 in immune response modulation. It exhibits immunomodulatory effects by influencing leukocyte migration, regulating cytokine production, and modulating the activity of immune cells. This aspect of TIMP-1 function contributes to its involvement in various equine inflammatory diseases and immune-mediated disorders.

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