Equine Ins antibody and antigen (recombinant protein)

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-EQU-Ins-Ag01	Recombinant Equine Ins protein	3090
GMP-EQU-Ins-Ab01	Anti-Equine Ins mouse monoclonal antibody (mAb)	1953
GMP-EQU-Ins-Ab02	Anti-Equine Ins mouse monoclonal antibody (mAb)	1953
GMP-EQU-Ins-Ab03	Anti-Equine Ins human monoclonal antibody (mAb)	1953
GMP-EQU-Ins-Ab04	Anti-Equine Ins human monoclonal antibody (mAb)	1953

Size： 1mg | 10mg | 100mg

Product Description

Cat No. of Products	GMP-EQU-Ins-Ag01
Product Name	Recombinant Equine Ins protein
Target/Biomarker	Equine Insulin (Ins)
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Equine Insulin antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in Ins level test of animal Equine/Horse with Diabetes mellitus.
Tag	His
Products description	Recombinant Equine Ins protein was expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-EQU-Ins-Ab01, GMP-EQU-Ins-Ab02
Product Name	Anti-Equine Ins mouse monoclonal antibody (mAb)
Target/Biomarker	Equine Insulin (Ins)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Equine Insulin antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Ins antibodies in Ins level test of animal Equine/Horse with Diabetes mellitus.
Tag	mFc
Products description	Anti-Equine Ins mouse monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Ins antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-EQU-Ins-Ab03, GMP-EQU-Ins-Ab04
Product Name	Anti-Equine Ins human monoclonal antibody (mAb)
Target/Biomarker	Equine Insulin (Ins)
Expression platform	CHO
Isotypes	Human IgG1
Bioactivity validation	Recombinant Equine Insulin antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Ins antibodies in Ins level test of animal Equine/Horse with Diabetes mellitus.
Tag	hFc
Products description	Anti-Equine Ins human monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Ins antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Target/Biomarker information

Equine Insulin, an intricate peptide hormone comprising 51 amino acids, reigns supreme as a cornerstone of glucose regulation in horses. Produced and secreted by the beta cells nestled within the equine pancreas, it orchestrates a symphony of metabolic processes that dictate how horses utilize glucose for energy and storage. At its core, Equine Insulin serves as the conductor for cellular glucose uptake. Upon its release into circulation, it seeks out insulin receptors on the surfaces of target cells, notably those found in skeletal muscle and adipose tissue. This binding event sets in motion a finely tuned series of intracellular signaling pathways, culminating in the translocation of glucose transporters (GLUT4) to the cell membrane. These transporters act as the molecular gatekeepers that permit glucose entry into the cell, where it can be either converted into energy through glycolysis or stored as glycogen for future energy demands. The secretion of Equine Insulin is intricately linked to blood glucose levels. After a horse's meal, when glucose levels surge, beta cells respond by releasing insulin, effectively facilitating glucose uptake into cells and leading to a decline in blood glucose levels, restoring metabolic equilibrium. Conversely, during fasting or times of heightened energy demand, Equine Insulin secretion diminishes, allowing stored glucose to be mobilized and released into circulation to maintain vital glucose homeostasis.

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