Equine Haptoglobin antibody and antigen (recombinant protein)

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-EQU-Haptoglobin-Ag01	Recombinant Equine Haptoglobin protein	3090
GMP-EQU-Haptoglobin-Ab01	Anti-Equine Haptoglobin mouse monoclonal antibody (mAb)	1953
GMP-EQU-Haptoglobin-Ab02	Anti-Equine Haptoglobin mouse monoclonal antibody (mAb)	1953
GMP-EQU-Haptoglobin-Ab03	Anti-Equine Haptoglobin human monoclonal antibody (mAb)	1953
GMP-EQU-Haptoglobin-Ab04	Anti-Equine Haptoglobin human monoclonal antibody (mAb)	1953

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Product Description

Cat No. of Products	GMP-EQU-Haptoglobin-Ag01
Product Name	Recombinant Equine Haptoglobin protein
Target/Biomarker	Equine Haptoglobin (HP)
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Equine Haptoglobin antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in HP level test of animal Equine/Horse with milk fever, ketosis, severe mastitis, acute severe metritis, retained placenta and chronic endometritis.
Tag	His
Products description	Recombinant Equine Haptoglobin protein was expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-EQU-Haptoglobin-Ab01, GMP-EQU-Haptoglobin-Ab02
Product Name	Anti-Equine Haptoglobin mouse monoclonal antibody (mAb)
Target/Biomarker	Equine Haptoglobin (HP)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Equine Haptoglobin antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-HP antibodies in HP level test of animal Equine/Horse with milk fever, ketosis, severe mastitis, acute severe metritis, retained placenta and chronic endometritis.
Tag	mFc
Products description	Anti-Equine Haptoglobin mouse monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-HP antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-EQU-Haptoglobin-Ab03, GMP-EQU-Haptoglobin-Ab04
Product Name	Anti-Equine Haptoglobin human monoclonal antibody (mAb)
Target/Biomarker	Equine Haptoglobin (HP)
Expression platform	CHO
Isotypes	Human IgG1
Bioactivity validation	Recombinant Equine Haptoglobin antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-HP antibodies in HP level test of animal Equine/Horse with milk fever, ketosis, severe mastitis, acute severe metritis, retained placenta and chronic endometritis.
Tag	hFc
Products description	Anti-Equine Haptoglobin human monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-HP antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Target/Biomarker information

Equine Haptoglobin is an acute phase protein with a significant role in the inflammatory response and as a biomarker of tissue injury in horses. When a horse experiences inflammation, infection, or tissue damage, the liver is prompted to synthesize and release increased amounts of haptoglobin into the bloodstream. The primary function of haptoglobin in the horse, as in other mammals, is to bind free hemoglobin released during intravascular hemolysis. This binding is crucial because free hemoglobin can be toxic due to its oxidative properties. The haptoglobin-hemoglobin complexes are then removed from circulation by the liver, which also helps conserve valuable iron that can be reused for erythropoiesis (the production of new red blood cells). In the context of veterinary medicine, measuring haptoglobin levels in horses provides veterinarians with important diagnostic information. Elevated haptoglobin can indicate various conditions, including respiratory infections, systemic inflammatory response syndrome (SIRS), gastrointestinal diseases causing systemic inflammation (such as colitis or enteritis), and muscular injuries. Since haptoglobin levels can rise rapidly following the onset of an inflammatory stimulus, it is a useful indicator of acute inflammation. Monitoring haptoglobin can also be valuable in managing equine health, particularly in the context of performance horses, where early detection of subclinical disease can prevent further injury and aid in timely treatment. For example, in equine athletes, elevated haptoglobin levels might suggest muscle damage or other inflammatory conditions that could impair performance, necessitating rest and recovery. Furthermore, haptoglobin levels are utilized to monitor the disease progression and response to treatment in horses. A decrease in haptoglobin concentrations during recovery can signal a successful response to treatment, while persistent elevation may indicate ongoing inflammation or insufficient therapeutic intervention. However, it's essential to interpret haptoglobin levels in conjunction with other clinical findings and laboratory tests since it is a non-specific marker. Other acute phase proteins and complete blood counts, along with clinical signs and history, contribute to a comprehensive assessment of the horse's health. In summary, equine haptoglobin is an important protein for veterinarians to consider when evaluating the health status of horses. Its role in binding free hemoglobin protects the body from oxidative damage, and its levels in blood can serve as a sensitive biomarker for inflammation and tissue injury. This makes haptoglobin a valuable tool in diagnosing, monitoring, and managing various health conditions in horses.

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