Equine FIB antibody and antigen (recombinant protein)

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-EQU-FIB-Ag01	Recombinant Equine FIB protein	3090
GMP-EQU-FIB-Ab01	Anti-Equine FIB mouse monoclonal antibody (mAb)	1953
GMP-EQU-FIB-Ab02	Anti-Equine FIB mouse monoclonal antibody (mAb)	1953
GMP-EQU-FIB-Ab03	Anti-Equine FIB human monoclonal antibody (mAb)	1953
GMP-EQU-FIB-Ab04	Anti-Equine FIB human monoclonal antibody (mAb)	1953

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Product Description

Cat No. of Products	GMP-EQU-FIB-Ag01
Product Name	Recombinant Equine FIB protein
Target/Biomarker	Equine Fibrinogen (FIB)
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Equine Fibrinogen antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in FIB level test of animal Equine/Horse with congenital afibrinogenemia, congenital hypofibrinogenemia, fibrinogen storage disease, congenital dysfibrinogenemia, hereditary fibrinogen Aα-Chain amyloidosis, acquired dysfibrinogenemia, congenital hypodysfibrinogenemia, and cryofibrinogenemia.
Tag	His
Products description	Recombinant Equine FIB protein was expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-EQU-FIB-Ab01, GMP-EQU-FIB-Ab02
Product Name	Anti-Equine FIB mouse monoclonal antibody (mAb)
Target/Biomarker	Equine Fibrinogen (FIB)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Equine Fibrinogen antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-FIB antibodies in FIB level test of animal Equine/Horse with congenital afibrinogenemia, congenital hypofibrinogenemia, fibrinogen storage disease, congenital dysfibrinogenemia, hereditary fibrinogen Aα-Chain amyloidosis, acquired dysfibrinogenemia, congenital hypodysfibrinogenemia, and cryofibrinogenemia.
Tag	mFc
Products description	Anti-Equine FIB mouse monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-FIB antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-EQU-FIB-Ab03, GMP-EQU-FIB-Ab04
Product Name	Anti-Equine FIB human monoclonal antibody (mAb)
Target/Biomarker	Equine Fibrinogen (FIB)
Expression platform	CHO
Isotypes	Human IgG1
Bioactivity validation	Recombinant Equine Fibrinogen antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-FIB antibodies in FIB level test of animal Equine/Horse with congenital afibrinogenemia, congenital hypofibrinogenemia, fibrinogen storage disease, congenital dysfibrinogenemia, hereditary fibrinogen Aα-Chain amyloidosis, acquired dysfibrinogenemia, congenital hypodysfibrinogenemia, and cryofibrinogenemia.
Tag	hFc
Products description	Anti-Equine FIB human monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-FIB antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Target/Biomarker information

Equine Fibrinogen, a linchpin of the equine circulatory system, merits a closer examination. Structurally, it is a glycoprotein of notable complexity, composed of three intertwined polypeptide chains: alpha, beta, and gamma. These chains unite to form a large hexameric molecule with a molecular mass of approximately 340 kDa. Synthesized predominantly in the liver, equine fibrinogen is released into the bloodstream, poised for its critical role in maintaining hemostasis. At the heart of Equine Fibrinogen's function lies its conversion to fibrin, an event central to blood clot formation. When vascular injury or other hemostatic triggers occur, the enzyme thrombin catalyzes the cleavage of FIB's alpha and beta chains. This enzymatic reaction liberates fibrin, which undergoes rapid polymerization, creating long strands. These strands intertwine to form a meshwork, the scaffold of a blood clot that effectively halts bleeding. The dynamic nature of Equine Fibrinogen renders it a versatile and responsive biomarker. During episodes of inflammation, infection, or tissue injury, its synthesis escalates as part of the acute-phase response. This heightened production equips the body with an enhanced capacity to form blood clots at sites of injury, reinforcing the physiological defense mechanisms against potential threats.

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