Equine Dig antibody and antigen (recombinant protein)

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-EQU-Dig-Ag01	Recombinant Equine Dig protein	3090
GMP-EQU-Dig-Ab01	Anti-Equine Dig mouse monoclonal antibody (mAb)	1953
GMP-EQU-Dig-Ab02	Anti-Equine Dig mouse monoclonal antibody (mAb)	1953
GMP-EQU-Dig-Ab03	Anti-Equine Dig human monoclonal antibody (mAb)	1953
GMP-EQU-Dig-Ab04	Anti-Equine Dig human monoclonal antibody (mAb)	1953

Size： 1mg | 10mg | 100mg

Product Description

Cat No. of Products	GMP-EQU-Dig-Ag01
Product Name	Recombinant Equine Dig protein
Target/Biomarker	Equine Digoxigenin (Dig)
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Equine Digoxigenin antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in Dig level test of animal Equine/Horse with N/A.
Tag	His
Products description	Recombinant Equine Dig protein was expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-EQU-Dig-Ab01, GMP-EQU-Dig-Ab02
Product Name	Anti-Equine Dig mouse monoclonal antibody (mAb)
Target/Biomarker	Equine Digoxigenin (Dig)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Equine Digoxigenin antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Dig antibodies in Dig level test of animal Equine/Horse with N/A.
Tag	mFc
Products description	Anti-Equine Dig mouse monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Dig antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-EQU-Dig-Ab03, GMP-EQU-Dig-Ab04
Product Name	Anti-Equine Dig human monoclonal antibody (mAb)
Target/Biomarker	Equine Digoxigenin (Dig)
Expression platform	CHO
Isotypes	Human IgG1
Bioactivity validation	Recombinant Equine Digoxigenin antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Dig antibodies in Dig level test of animal Equine/Horse with N/A.
Tag	hFc
Products description	Anti-Equine Dig human monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Dig antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Target/Biomarker information

Equine Dig, or the measurement of digoxin levels in horses, holds a pivotal role in equine cardiology. To delve deeper into what it entails, we must understand the significance of digoxin itself. Digoxin is a cardiac glycoside derived from the leaves of the foxglove plant (Digitalis purpurea). Its therapeutic properties in both humans and horses revolve around its ability to enhance the contractility of cardiac muscle fibers while reducing heart rate. In the equine world, the measurement of Horse Dig primarily involves quantifying the concentration of digoxin in the horse's circulatory system. It's a meticulous process carried out through immunoassays, allowing veterinarians to gain precise insights into the pharmacokinetics of digoxin within the equine physiology. Digoxin operates by inhibiting the sodium-potassium pump in myocardial cells, causing an elevation in intracellular calcium levels. This, in turn, increases the force of myocardial contraction, thereby enhancing the heart's pumping efficiency. Simultaneously, digoxin exerts an anti-arrhythmic effect by reducing the frequency of atrioventricular node firing, especially useful in horses with atrial fibrillation, a condition characterized by irregular heart rhythms. Understanding what Equine Dig represents is integral in comprehending its clinical importance. It serves as a window into the status of a horse's cardiovascular health, specifically in the context of digoxin therapy. Digoxin is employed to manage various cardiac conditions in horses, most notably congestive heart failure and atrial fibrillation.

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