Equine BNP antibody and antigen (recombinant protein)

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-EQU-BNP-Ag01	Recombinant Equine BNP protein	3090
GMP-EQU-BNP-Ab01	Anti-Equine BNP mouse monoclonal antibody (mAb)	1953
GMP-EQU-BNP-Ab02	Anti-Equine BNP mouse monoclonal antibody (mAb)	1953
GMP-EQU-BNP-Ab03	Anti-Equine BNP human monoclonal antibody (mAb)	1953
GMP-EQU-BNP-Ab04	Anti-Equine BNP human monoclonal antibody (mAb)	1953

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Product Description

Cat No. of Products	GMP-EQU-BNP-Ag01
Product Name	Recombinant Equine BNP protein
Target/Biomarker	Equine B-type natriuretic peptide (DEV)
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Equine B-type natriuretic peptide antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in DEV level test of animal Equine/Horse with Cardiovascular Disease.
Tag	His
Products description	Recombinant Equine BNP protein was expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-EQU-BNP-Ab01, GMP-EQU-BNP-Ab02
Product Name	Anti-Equine BNP mouse monoclonal antibody (mAb)
Target/Biomarker	Equine B-type natriuretic peptide (DEV)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Equine B-type natriuretic peptide antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-DEV antibodies in DEV level test of animal Equine/Horse with Cardiovascular Disease.
Tag	mFc
Products description	Anti-Equine BNP mouse monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-DEV antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-EQU-BNP-Ab03, GMP-EQU-BNP-Ab04
Product Name	Anti-Equine BNP human monoclonal antibody (mAb)
Target/Biomarker	Equine B-type natriuretic peptide (DEV)
Expression platform	CHO
Isotypes	Human IgG1
Bioactivity validation	Recombinant Equine B-type natriuretic peptide antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-DEV antibodies in DEV level test of animal Equine/Horse with Cardiovascular Disease.
Tag	hFc
Products description	Anti-Equine BNP human monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-DEV antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Target/Biomarker information

Equine B-type Natriuretic Peptide, or Equine BNP, is a remarkable peptide hormone that forms an integral part of the cardiovascular system in horses (Equus ferus caballus). It belongs to a family of natriuretic peptides, which are substances with profound effects on blood pressure regulation, fluid balance, and overall cardiovascular homeostasis. In the equine context, BNP is particularly noteworthy for its role in responding to cardiac stress and maintaining hemodynamic equilibrium. Structurally, Equine BNP is comprised of a sequence of amino acids, and upon release into the bloodstream, it can be enzymatically cleaved to produce an active form known as BNP-32. This active form carries out its physiological functions by binding to specific receptors in various tissues, particularly in the kidneys and blood vessels. The primary source of Equine BNP synthesis is the cardiac muscle itself, specifically the ventricular cardiomyocytes. When the heart faces increased pressure or stretch, a common occurrence during certain cardiac pathologies or conditions that demand increased cardiac output (e.g., exercise), these cells respond by secreting Equine BNP into the circulation. The actions of Equine BNP are remarkable and have a profound impact on cardiovascular physiology. One of its main effects is vasodilation, which means it causes the blood vessels to relax and widen. This vasodilatory effect reduces peripheral vascular resistance, resulting in decreased afterload on the heart. Additionally, Equine BNP promotes diuresis, which means it enhances urine production. By increasing urine output, Equine BNP helps to eliminate excess fluid from the body, reducing blood volume and further alleviating the heart's workload.

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