Equine ANP antibody and antigen (recombinant protein)

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-EQU-ANP-Ag01	Recombinant Equine ANP protein	3090
GMP-EQU-ANP-Ab01	Anti-Equine ANP mouse monoclonal antibody (mAb)	1953
GMP-EQU-ANP-Ab02	Anti-Equine ANP mouse monoclonal antibody (mAb)	1953
GMP-EQU-ANP-Ab03	Anti-Equine ANP human monoclonal antibody (mAb)	1953
GMP-EQU-ANP-Ab04	Anti-Equine ANP human monoclonal antibody (mAb)	1953

Size： 1mg | 10mg | 100mg

Product Description

Cat No. of Products	GMP-EQU-ANP-Ag01
Product Name	Recombinant Equine ANP protein
Target/Biomarker	Equine atrial natriuretic peptide ()
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Equine atrial natriuretic peptide antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in level test of animal Equine/Horse with hypertension, cardiac hypertrophy and heart failure.
Tag	His
Products description	Recombinant Equine ANP protein was expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-EQU-ANP-Ab01, GMP-EQU-ANP-Ab02
Product Name	Anti-Equine ANP mouse monoclonal antibody (mAb)
Target/Biomarker	Equine atrial natriuretic peptide ()
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Equine atrial natriuretic peptide antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti- antibodies in level test of animal Equine/Horse with hypertension, cardiac hypertrophy and heart failure.
Tag	mFc
Products description	Anti-Equine ANP mouse monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti- antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-EQU-ANP-Ab03, GMP-EQU-ANP-Ab04
Product Name	Anti-Equine ANP human monoclonal antibody (mAb)
Target/Biomarker	Equine atrial natriuretic peptide ()
Expression platform	CHO
Isotypes	Human IgG1
Bioactivity validation	Recombinant Equine atrial natriuretic peptide antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti- antibodies in level test of animal Equine/Horse with hypertension, cardiac hypertrophy and heart failure.
Tag	hFc
Products description	Anti-Equine ANP human monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti- antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Target/Biomarker information

Atrial Natriuretic Peptide (ANP), a biologically active peptide hormone, holds a pivotal role in the equine cardiovascular system. This 28-amino acid molecule is primarily synthesized and secreted by the cardiac atria in response to increased cardiac wall tension, pressure, and stretch. ANP's synthesis is regulated by various factors, including the distension of atrial myocytes, neurohormonal influences, and circulating fluid volume. Once released into the bloodstream, ANP exerts a multifaceted influence on cardiovascular and renal physiology. ANP's most prominent action is its vasodilatory effect on blood vessels, particularly on the afferent arterioles within the kidneys. This vasodilation increases renal blood flow and the glomerular filtration rate, ultimately leading to enhanced sodium and water excretion in the urine. By opposing the renin-angiotensin-aldosterone system (RAAS), ANP reduces sodium reabsorption in the distal tubules of the nephron. This dual mechanism of action effectively decreases blood volume and blood pressure, serving as a counterbalance to the vasoconstrictive and sodium-retentive effects of the RAAS. Moreover, ANP's impact extends beyond the cardiovascular system. It exerts an inhibitory effect on the hypothalamus and pituitary gland, suppressing the release of antidiuretic hormone (ADH), also known as vasopressin. This further enhances the excretion of water and electrolytes, aiding in the regulation of body fluid balance. In summary, ANP acts as a guardian of cardiovascular and renal homeostasis in horses, finely tuning blood pressure, fluid balance, and electrolyte concentrations. Its intricate regulatory mechanisms make it a crucial biomarker in equine medicine and a key player in maintaining overall equine health.

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