Equine AI antibody and antigen (recombinant protein)

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-EQU-AI-Ag01	Recombinant Equine AI protein	3090
GMP-EQU-AI-Ab01	Anti-Equine AI mouse monoclonal antibody (mAb)	1953
GMP-EQU-AI-Ab02	Anti-Equine AI mouse monoclonal antibody (mAb)	1953
GMP-EQU-AI-Ab03	Anti-Equine AI human monoclonal antibody (mAb)	1953
GMP-EQU-AI-Ab04	Anti-Equine AI human monoclonal antibody (mAb)	1953

Size： 1mg | 10mg | 100mg

Product Description

Cat No. of Products	GMP-EQU-AI-Ag01
Product Name	Recombinant Equine AI protein
Target/Biomarker	Equine Angiotensin (MDV)
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Equine Angiotensin antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in MDV level test of animal Equine/Horse with hypertension, renal disease, and congestive heart failure.
Tag	His
Products description	Recombinant Equine AI protein was expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-EQU-AI-Ab01, GMP-EQU-AI-Ab02
Product Name	Anti-Equine AI mouse monoclonal antibody (mAb)
Target/Biomarker	Equine Angiotensin (MDV)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Equine Angiotensin antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-MDV antibodies in MDV level test of animal Equine/Horse with hypertension, renal disease, and congestive heart failure.
Tag	mFc
Products description	Anti-Equine AI mouse monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-MDV antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-EQU-AI-Ab03, GMP-EQU-AI-Ab04
Product Name	Anti-Equine AI human monoclonal antibody (mAb)
Target/Biomarker	Equine Angiotensin (MDV)
Expression platform	CHO
Isotypes	Human IgG1
Bioactivity validation	Recombinant Equine Angiotensin antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-MDV antibodies in MDV level test of animal Equine/Horse with hypertension, renal disease, and congestive heart failure.
Tag	hFc
Products description	Anti-Equine AI human monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-MDV antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Target/Biomarker information

Equine Alpha-2 Macroglobulin (EAMG) is an intriguing biomarker that holds profound significance in understanding the health and physiology of horses. Its structural and functional complexity makes it a key player in the equine biological landscape. At a molecular level, EAMG is a high-molecular-weight glycoprotein composed of four identical subunits arranged in a tetrameric structure. This unique architecture grants EAMG its remarkable versatility and functionality. Its primary role lies in the inhibition of proteases, enzymes that play pivotal roles in various physiological processes. EAMG acts as a sentinel, intercepting proteases involved in inflammatory responses, tissue remodeling, and pathogen defense. By inactivating these proteases, EAMG helps maintain tissue integrity and prevent excessive inflammation, thereby safeguarding the horse's health. Beyond its role as a protease inhibitor, EAMG has a multifaceted immunomodulatory function. During an immune challenge or infection, the horse's body mounts an acute-phase response. EAMG is an integral part of this response, with its concentration in the blood rising significantly. This increase aids in the clearance of pathogens, such as bacteria and viruses, by neutralizing their protease weaponry. Moreover, EAMG helps orchestrate the inflammatory response, ensuring it is targeted and controlled to prevent collateral damage to healthy tissues. Equally fascinating is EAMG's involvement in the transportation of vital molecules within the horse's circulatory system. This biomarker acts as a molecular courier, shuttling hormones, vitamins, growth factors, and other essential compounds to their respective destinations within the horse's body. This function is fundamental to the regulation of numerous metabolic processes, including growth, tissue repair, and overall homeostasis. In summary, Equine Alpha-2 Macroglobulin (EAMG) is a molecular marvel within the equine system. Its structural complexity and multifunctional nature make it an essential player in maintaining the health and well-being of horses.

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