Equine ACTH antibody and antigen (recombinant protein)

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-EQU-ACTH-Ag01	Recombinant Equine ACTH protein	3090
GMP-EQU-ACTH-Ab01	Anti-Equine ACTH mouse monoclonal antibody (mAb)	1953
GMP-EQU-ACTH-Ab02	Anti-Equine ACTH mouse monoclonal antibody (mAb)	1953
GMP-EQU-ACTH-Ab03	Anti-Equine ACTH human monoclonal antibody (mAb)	1953
GMP-EQU-ACTH-Ab04	Anti-Equine ACTH human monoclonal antibody (mAb)	1953

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Product Description

Cat No. of Products	GMP-EQU-ACTH-Ag01
Product Name	Recombinant Equine ACTH protein
Target/Biomarker	Equine Adrenocorticotropic Hormone (ACTH)
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Equine Adrenocorticotropic Hormone antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in ACTH level test of animal Equine/Horse with pituitary or adrenal malfunction, pituitary tumor, adrenal tumor, lung tumor.
Tag	His
Products description	Recombinant Equine ACTH protein was expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-EQU-ACTH-Ab01, GMP-EQU-ACTH-Ab02
Product Name	Anti-Equine ACTH mouse monoclonal antibody (mAb)
Target/Biomarker	Equine Adrenocorticotropic Hormone (ACTH)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Equine Adrenocorticotropic Hormone antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-ACTH antibodies in ACTH level test of animal Equine/Horse with pituitary or adrenal malfunction, pituitary tumor, adrenal tumor, lung tumor.
Tag	mFc
Products description	Anti-Equine ACTH mouse monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-ACTH antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-EQU-ACTH-Ab03, GMP-EQU-ACTH-Ab04
Product Name	Anti-Equine ACTH human monoclonal antibody (mAb)
Target/Biomarker	Equine Adrenocorticotropic Hormone (ACTH)
Expression platform	CHO
Isotypes	Human IgG1
Bioactivity validation	Recombinant Equine Adrenocorticotropic Hormone antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-ACTH antibodies in ACTH level test of animal Equine/Horse with pituitary or adrenal malfunction, pituitary tumor, adrenal tumor, lung tumor.
Tag	hFc
Products description	Anti-Equine ACTH human monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-ACTH antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Target/Biomarker information

Adrenocorticotropic Hormone (ACTH) takes center stage in the intricate web of equine endocrinology, serving as the linchpin that orchestrates the horse's response to stressors and maintains hormonal balance. Structurally, ACTH is a 39-amino acid peptide hormone synthesized and secreted by the anterior pituitary gland. It belongs to the melanocortin family, a group of hormones with multifaceted physiological roles. ACTH's primary mission lies in its regulation of the adrenal glands, specifically the adrenal cortex. When a horse encounters stressors or experiences shifts in its internal environment, the hypothalamus promptly releases corticotropin-releasing hormone (CRH). CRH, in turn, stimulates the anterior pituitary gland to release ACTH into the bloodstream. In its journey through circulation, ACTH reaches the adrenal cortex, where it binds to specific receptors on the surface of adrenal cells. This binding event triggers intracellular processes that culminate in the synthesis and release of cortisol, a corticosteroid hormone. Often referred to as the "stress hormone," cortisol exerts a wide array of effects on equine physiology. Cortisol holds the reins in regulating metabolism, influencing immune function, and steering the horse's response to stressors. It elevates blood glucose levels, modulates immune responses, and orchestrates anti-inflammatory actions. Furthermore, cortisol influences protein and fat metabolism, maintains electrolyte balance, and exerts its influence on cardiovascular function.

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