Equine Aβ42 antibody and antigen (recombinant protein)

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-EQU-AB42-Ag01	Recombinant Equine Aβ42 protein	3090
GMP-EQU-AB42-Ab01	Anti-Equine Aβ42 mouse monoclonal antibody (mAb)	1953
GMP-EQU-AB42-Ab02	Anti-Equine Aβ42 mouse monoclonal antibody (mAb)	1953
GMP-EQU-AB42-Ab03	Anti-Equine Aβ42 human monoclonal antibody (mAb)	1953
GMP-EQU-AB42-Ab04	Anti-Equine Aβ42 human monoclonal antibody (mAb)	1953

Size： 1mg | 10mg | 100mg

Product Description

Cat No. of Products	GMP-EQU-AB42-Ag01
Product Name	Recombinant Equine Aβ42 protein
Target/Biomarker	Equine beta-amyloid 42 (AEV)
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Equine beta-amyloid 42 antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in AEV level test of animal Equine/Horse with Alzheimer Disease(AD).
Tag	His
Products description	Recombinant Equine Aβ42 protein was expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-EQU-AB42-Ab01, GMP-EQU-AB42-Ab02
Product Name	Anti-Equine Aβ42 mouse monoclonal antibody (mAb)
Target/Biomarker	Equine beta-amyloid 42 (AEV)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Equine beta-amyloid 42 antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-AEV antibodies in AEV level test of animal Equine/Horse with Alzheimer Disease(AD).
Tag	mFc
Products description	Anti-Equine Aβ42 mouse monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-AEV antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-EQU-AB42-Ab03, GMP-EQU-AB42-Ab04
Product Name	Anti-Equine Aβ42 human monoclonal antibody (mAb)
Target/Biomarker	Equine beta-amyloid 42 (AEV)
Expression platform	CHO
Isotypes	Human IgG1
Bioactivity validation	Recombinant Equine beta-amyloid 42 antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-AEV antibodies in AEV level test of animal Equine/Horse with Alzheimer Disease(AD).
Tag	hFc
Products description	Anti-Equine Aβ42 human monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-AEV antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Target/Biomarker information

Equine Amyloid-beta 42 (Aβ42) emerges as a pivotal molecule in equine neuroscience, occupying a central role in our understanding of neurodegenerative conditions affecting our noble equine companions. Comprising 42 amino acids, Aβ42 is a fragment of the amyloid precursor protein (APP) and stands as a critical component in the formation of amyloid plaques within the equine brain. These plaques, primarily composed of Aβ42, have come to symbolize cognitive decline in horses, most notably in cases of equine cognitive dysfunction syndrome (ECDS). The genesis of Aβ42 involves the proteolytic cleavage of APP, a process mediated by β-secretase and γ-secretase enzymes. In horses afflicted by ECDS, a perturbation in Aβ42 metabolism and clearance results in its aggregation, leading to the accumulation of amyloid plaques. These plaques pose a direct threat to normal neuronal function, contributing substantially to the cognitive and memory impairments observed in affected horses. The ramifications of Aβ42 aggregation extend further, encompassing a cascade of deleterious effects. These include neuroinflammation, oxidative stress, and synaptic dysfunction, all of which collectively contribute to the progressive cognitive deficits witnessed in horses suffering from ECDS.

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