Equine Aβ40 antibody and antigen (recombinant protein)

 Download 

Product information

Catalog No.	Description	US $ Price (per mg)
GMP-EQU-AB40-Ag01	Recombinant Equine Aβ40 protein	3090
GMP-EQU-AB40-Ab01	Anti-Equine Aβ40 mouse monoclonal antibody (mAb)	1953
GMP-EQU-AB40-Ab02	Anti-Equine Aβ40 mouse monoclonal antibody (mAb)	1953
GMP-EQU-AB40-Ab03	Anti-Equine Aβ40 human monoclonal antibody (mAb)	1953
GMP-EQU-AB40-Ab04	Anti-Equine Aβ40 human monoclonal antibody (mAb)	1953

Size： 1mg | 10mg | 100mg

Product Description

Cat No. of Products	GMP-EQU-AB40-Ag01
Product Name	Recombinant Equine Aβ40 protein
Target/Biomarker	Equine beta-amyloid 40 (REV)
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Equine beta-amyloid 40 antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in REV level test of animal Equine/Horse with Alzheimer Disease(AD).
Tag	His
Products description	Recombinant Equine Aβ40 protein was expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-EQU-AB40-Ab01, GMP-EQU-AB40-Ab02
Product Name	Anti-Equine Aβ40 mouse monoclonal antibody (mAb)
Target/Biomarker	Equine beta-amyloid 40 (REV)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Equine beta-amyloid 40 antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-REV antibodies in REV level test of animal Equine/Horse with Alzheimer Disease(AD).
Tag	mFc
Products description	Anti-Equine Aβ40 mouse monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-REV antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-EQU-AB40-Ab03, GMP-EQU-AB40-Ab04
Product Name	Anti-Equine Aβ40 human monoclonal antibody (mAb)
Target/Biomarker	Equine beta-amyloid 40 (REV)
Expression platform	CHO
Isotypes	Human IgG1
Bioactivity validation	Recombinant Equine beta-amyloid 40 antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-REV antibodies in REV level test of animal Equine/Horse with Alzheimer Disease(AD).
Tag	hFc
Products description	Anti-Equine Aβ40 human monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-REV antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

Click to get more Data / Case study about the product.

Target/Biomarker information

Equine Amyloid-beta 40 (Aβ40) is a remarkable molecule in equine neuroscience, occupying a central role in our understanding of neurodegenerative conditions affecting our noble equine companions. Comprising 40 amino acids, Aβ40 is a fragment of the amyloid precursor protein (APP) and stands as a critical component in the formation of amyloid plaques within the equine brain. These plaques, primarily composed of Aβ40, have come to symbolize cognitive decline in horses, most notably in cases of equine cognitive dysfunction syndrome (ECDS). The genesis of Aβ40 involves proteolytic cleavage of APP, a process mediated by β-secretase and γ-secretase enzymes. In horses afflicted by ECDS, a perturbation in Aβ40 metabolism and clearance results in its aggregation, leading to the accumulation of amyloid plaques. These plaques disrupt normal neuronal function, contributing substantially to the cognitive deficits seen in affected horses. The ramifications of Aβ40 aggregation extend further, encompassing a cascade of deleterious effects. These include neuroinflammation, oxidative stress, and synaptic dysfunction, all of which collectively contribute to the progressive cognitive deficits witnessed in horses suffering from ECDS.

About GDU