Canine sTREM2 antibody and antigen (recombinant protein)

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-CAN-sTREM2-Ag01	Recombinant Canine sTREM2 protein	3090
GMP-CAN-sTREM2-Ab01	Anti-Canine sTREM2 mouse monoclonal antibody (mAb)	1953
GMP-CAN-sTREM2-Ab02	Anti-Canine sTREM2 mouse monoclonal antibody (mAb)	1953
GMP-CAN-sTREM2-Ab03	Anti-Canine sTREM2 human monoclonal antibody (mAb)	1953
GMP-CAN-sTREM2-Ab04	Anti-Canine sTREM2 human monoclonal antibody (mAb)	1953

Size： 1mg | 10mg | 100mg

Product Description

Cat No. of Products	GMP-CAN-sTREM2-Ag01
Product Name	Recombinant Canine sTREM2 protein
Target/Biomarker	Canine Soluble Fragment Of Triggering Receptor Expressed On Myeloid Cells 2 (sTREM2)
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Canine Soluble Fragment Of Triggering Receptor Expressed On Myeloid Cells 2 antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in sTREM2 level test of animal Dog/Canine with Alzheimer Disease(AD).
Tag	His
Products description	Recombinant Canine sTREM2 protein was expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-CAN-sTREM2-Ab01, GMP-CAN-sTREM2-Ab02
Product Name	Anti-Canine sTREM2 mouse monoclonal antibody (mAb)
Target/Biomarker	Canine Soluble Fragment Of Triggering Receptor Expressed On Myeloid Cells 2 (sTREM2)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Canine Soluble Fragment Of Triggering Receptor Expressed On Myeloid Cells 2 antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-sTREM2 antibodies in sTREM2 level test of animal Dog/Canine with Alzheimer Disease(AD).
Tag	mFc
Products description	Anti-Canine sTREM2 mouse monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-sTREM2 antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-CAN-sTREM2-Ab03, GMP-CAN-sTREM2-Ab04
Product Name	Anti-Canine sTREM2 human monoclonal antibody (mAb)
Target/Biomarker	Canine Soluble Fragment Of Triggering Receptor Expressed On Myeloid Cells 2 (sTREM2)
Expression platform	CHO
Isotypes	Human IgG1
Bioactivity validation	Recombinant Canine Soluble Fragment Of Triggering Receptor Expressed On Myeloid Cells 2 antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-sTREM2 antibodies in sTREM2 level test of animal Dog/Canine with Alzheimer Disease(AD).
Tag	hFc
Products description	Anti-Canine sTREM2 human monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-sTREM2 antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Target/Biomarker information

Soluble Triggering Receptor Expressed on Myeloid Cells-2 (sTREM2) emerges as a fascinating component of the canine immune and central nervous systems. In its soluble form, sTREM2 represents a distinct functional entity compared to its membrane-bound counterpart, TREM2. sTREM2 is generated through proteolytic cleavage of the membrane-bound receptor and can be found in the cerebrospinal fluid and bloodstream of dogs. Structurally, sTREM2 shares homology with its membrane-bound counterpart but lacks the transmembrane domain. Instead, it retains the extracellular domain responsible for interactions with various ligands and immune cells. This unique structure allows sTREM2 to exert its functions within the canine body. Functionally, sTREM2 is a key player in the modulation of immune responses within the central nervous system of dogs. Its presence is particularly notable in microglia, specialized immune cells resident in the brain. sTREM2 acts as a signaling molecule, influencing the behavior of microglia and other immune cells, especially in the context of neuroinflammation. Importantly, sTREM2's role goes beyond immune modulation. Research suggests that sTREM2 is involved in the phagocytic clearance of cellular debris and potentially contributes to the resolution of inflammation in the canine brain. This multifaceted functionality underscores the importance of sTREM2 in maintaining the balance between immune responses and neurological health in dogs.

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