Canine sST2 antibody and antigen (recombinant protein)

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-CAN-sST2-Ag01	Recombinant Canine sST2 protein	3090
GMP-CAN-sST2-Ab01	Anti-Canine sST2 mouse monoclonal antibody (mAb)	1953
GMP-CAN-sST2-Ab02	Anti-Canine sST2 mouse monoclonal antibody (mAb)	1953
GMP-CAN-sST2-Ab03	Anti-Canine sST2 human monoclonal antibody (mAb)	1953
GMP-CAN-sST2-Ab04	Anti-Canine sST2 human monoclonal antibody (mAb)	1953

Size： 1mg | 10mg | 100mg

Product Description

Cat No. of Products	GMP-CAN-sST2-Ag01
Product Name	Recombinant Canine sST2 protein
Target/Biomarker	Canine soluble ST2 (sST2)
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Canine soluble ST2 antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in sST2 level test of animal Dog/Canine with chronic and acute heart failure.
Tag	His
Products description	Recombinant Canine sST2 protein was expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-CAN-sST2-Ab01, GMP-CAN-sST2-Ab02
Product Name	Anti-Canine sST2 mouse monoclonal antibody (mAb)
Target/Biomarker	Canine soluble ST2 (sST2)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Canine soluble ST2 antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-sST2 antibodies in sST2 level test of animal Dog/Canine with chronic and acute heart failure.
Tag	mFc
Products description	Anti-Canine sST2 mouse monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-sST2 antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-CAN-sST2-Ab03, GMP-CAN-sST2-Ab04
Product Name	Anti-Canine sST2 human monoclonal antibody (mAb)
Target/Biomarker	Canine soluble ST2 (sST2)
Expression platform	CHO
Isotypes	Human IgG1
Bioactivity validation	Recombinant Canine soluble ST2 antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-sST2 antibodies in sST2 level test of animal Dog/Canine with chronic and acute heart failure.
Tag	hFc
Products description	Anti-Canine sST2 human monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-sST2 antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Target/Biomarker information

Soluble ST2 (sST2) in dogs is a soluble receptor that plays a pivotal role in the intricate web of immune responses, inflammation regulation, and cardiac health. It represents a key component in the cascade of events that unfold during cardiac stress, injury, or inflammation. In greater detail, sST2 is a product of the ST2 gene and exists in two primary forms: the membrane-bound ST2L and the soluble sST2. ST2L serves as a receptor for interleukin-33 (IL-33), an interleukin associated with anti-inflammatory and protective effects in the cardiovascular system. When IL-33 binds to membrane-bound ST2L, it contributes to cardiac protection and immune regulation. However, sST2, the soluble form of the ST2 receptor, acts as a decoy receptor, neutralizing the beneficial effects of IL-33. In dogs, sST2 is primarily secreted by cardiac cells, particularly cardiomyocytes, in response to cardiac stressors, inflammation, or injury. Its presence in the bloodstream indicates an activated immune response and an underlying cardiac issue.

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