Canine proBNP antibody and antigen (recombinant protein)

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-CAN-proBNP-Ag01	Recombinant Canine proBNP protein	3090
GMP-CAN-proBNP-Ab01	Anti-Canine proBNP mouse monoclonal antibody (mAb)	1953
GMP-CAN-proBNP-Ab02	Anti-Canine proBNP mouse monoclonal antibody (mAb)	1953
GMP-CAN-proBNP-Ab03	Anti-Canine proBNP human monoclonal antibody (mAb)	1953
GMP-CAN-proBNP-Ab04	Anti-Canine proBNP human monoclonal antibody (mAb)	1953

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Product Description

Cat No. of Products	GMP-CAN-proBNP-Ag01
Product Name	Recombinant Canine proBNP protein
Target/Biomarker	Canine pro B-type natriuretic peptide (proBNP)
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Canine pro B-type natriuretic peptide antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in proBNP level test of animal Dog/Canine with intrinsic cardiac dysfunction.
Tag	His
Products description	Recombinant Canine proBNP protein was expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-CAN-proBNP-Ab01, GMP-CAN-proBNP-Ab02
Product Name	Anti-Canine proBNP mouse monoclonal antibody (mAb)
Target/Biomarker	Canine pro B-type natriuretic peptide (proBNP)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Canine pro B-type natriuretic peptide antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-proBNP antibodies in proBNP level test of animal Dog/Canine with intrinsic cardiac dysfunction.
Tag	mFc
Products description	Anti-Canine proBNP mouse monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-proBNP antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-CAN-proBNP-Ab03, GMP-CAN-proBNP-Ab04
Product Name	Anti-Canine proBNP human monoclonal antibody (mAb)
Target/Biomarker	Canine pro B-type natriuretic peptide (proBNP)
Expression platform	CHO
Isotypes	Human IgG1
Bioactivity validation	Recombinant Canine pro B-type natriuretic peptide antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-proBNP antibodies in proBNP level test of animal Dog/Canine with intrinsic cardiac dysfunction.
Tag	hFc
Products description	Anti-Canine proBNP human monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-proBNP antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Target/Biomarker information

Canine proBNP, or Pro B-type natriuretic peptide, represents a remarkable advancement in our ability to understand and assess cardiac health in dogs. To grasp its significance fully, one must delve into its molecular intricacies and its role as a diagnostic beacon in the world of veterinary cardiology. At its core, proBNP is a prohormone synthesized predominantly within the cardiomyocytes, or heart muscle cells, of dogs. It belongs to the natriuretic peptide family, which includes B-type natriuretic peptide (BNP) and N-terminal pro B-type natriuretic peptide (NT-proBNP). When the heart encounters increased stress or stretching, a common occurrence in various cardiac conditions, proBNP undergoes enzymatic cleavage to release both BNP and NT-proBNP. BNP, the active hormone, exerts its effects by acting as a vasodilator. It plays a vital role in regulating blood pressure and fluid balance in the body. By relaxing blood vessels, BNP helps reduce blood pressure and alleviate the workload on the heart. However, its elevation in circulation signifies that the heart is struggling to maintain its normal function. This is where proBNP becomes a crucial indicator of cardiac distress. NT-proBNP, on the other hand, remains stable in circulation for an extended period, allowing for a broader diagnostic window. Together, BNP and NT-proBNP provide veterinarians with a comprehensive view of cardiac health and the extent of cardiac stress.

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