Canine p-tau231 antibody and antigen (recombinant protein)

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-CAN-p-tau231-Ag01	Recombinant Canine p-tau231 protein	3090
GMP-CAN-p-tau231-Ab01	Anti-Canine p-tau231 mouse monoclonal antibody (mAb)	1953
GMP-CAN-p-tau231-Ab02	Anti-Canine p-tau231 mouse monoclonal antibody (mAb)	1953
GMP-CAN-p-tau231-Ab03	Anti-Canine p-tau231 human monoclonal antibody (mAb)	1953
GMP-CAN-p-tau231-Ab04	Anti-Canine p-tau231 human monoclonal antibody (mAb)	1953

Size： 1mg | 10mg | 100mg

Product Description

Cat No. of Products	GMP-CAN-p-tau231-Ag01
Product Name	Recombinant Canine p-tau231 protein
Target/Biomarker	Canine Phospho-tau231 (p-tau231)
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Canine Phospho-tau231 antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in p-tau231 level test of animal Dog/Canine with Alzheimer Disease(AD).
Tag	His
Products description	Recombinant Canine p-tau231 protein was expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-CAN-p-tau231-Ab01, GMP-CAN-p-tau231-Ab02
Product Name	Anti-Canine p-tau231 mouse monoclonal antibody (mAb)
Target/Biomarker	Canine Phospho-tau231 (p-tau231)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Canine Phospho-tau231 antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-p-tau231 antibodies in p-tau231 level test of animal Dog/Canine with Alzheimer Disease(AD).
Tag	mFc
Products description	Anti-Canine p-tau231 mouse monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-p-tau231 antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-CAN-p-tau231-Ab03, GMP-CAN-p-tau231-Ab04
Product Name	Anti-Canine p-tau231 human monoclonal antibody (mAb)
Target/Biomarker	Canine Phospho-tau231 (p-tau231)
Expression platform	CHO
Isotypes	Human IgG1
Bioactivity validation	Recombinant Canine Phospho-tau231 antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-p-tau231 antibodies in p-tau231 level test of animal Dog/Canine with Alzheimer Disease(AD).
Tag	hFc
Products description	Anti-Canine p-tau231 human monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-p-tau231 antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Associated products

Target/Biomarker information

Canine p-tau231, the phosphorylated Tau Protein 231 variant specific to dogs, represents a molecular sentinel within the intricate landscape of canine neurobiology. At its core, it is a Tau protein that has undergone a precise biochemical modification – phosphorylation – specifically at residue 231. Tau proteins normally play a crucial role in stabilizing microtubules within neuronal cells, ensuring proper intracellular transport and the structural integrity of axons. However, in the context of neurodegenerative diseases, the narrative takes a different turn. Phosphorylation events can lead to the misfolding and aggregation of Tau proteins, and canine p-tau231 is no exception. It tends to aggregate and form neurofibrillary tangles (NFTs) within the neural tissues of affected dogs. These NFTs, reminiscent of those observed in human neurodegenerative diseases like Alzheimer's, are a pathological hallmark of various neurodegenerative conditions in dogs. The aggregation of p-tau231 in NFTs contributes to progressive neuronal dysfunction, cognitive decline, and motor disturbances, as seen in conditions such as canine Alzheimer's disease and specific encephalopathies.

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