Canine fFN antibody and antigen (recombinant protein)

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-CAN-fFN-Ag01	Recombinant Canine fFN protein	3090
GMP-CAN-fFN-Ab01	Anti-Canine fFN mouse monoclonal antibody (mAb)	1953
GMP-CAN-fFN-Ab02	Anti-Canine fFN mouse monoclonal antibody (mAb)	1953
GMP-CAN-fFN-Ab03	Anti-Canine fFN human monoclonal antibody (mAb)	1953
GMP-CAN-fFN-Ab04	Anti-Canine fFN human monoclonal antibody (mAb)	1953

Size： 1mg | 10mg | 100mg

Product Description

Cat No. of Products	GMP-CAN-fFN-Ag01
Product Name	Recombinant Canine fFN protein
Target/Biomarker	Canine Fetal fibronectin (fFN)
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Canine Fetal fibronectin antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in fFN level test of animal Dog/Canine with premature delivery.
Tag	His
Products description	Recombinant Canine fFN protein was expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-CAN-fFN-Ab01, GMP-CAN-fFN-Ab02
Product Name	Anti-Canine fFN mouse monoclonal antibody (mAb)
Target/Biomarker	Canine Fetal fibronectin (fFN)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Canine Fetal fibronectin antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-fFN antibodies in fFN level test of animal Dog/Canine with premature delivery.
Tag	mFc
Products description	Anti-Canine fFN mouse monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-fFN antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-CAN-fFN-Ab03, GMP-CAN-fFN-Ab04
Product Name	Anti-Canine fFN human monoclonal antibody (mAb)
Target/Biomarker	Canine Fetal fibronectin (fFN)
Expression platform	CHO
Isotypes	Human IgG1
Bioactivity validation	Recombinant Canine Fetal fibronectin antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-fFN antibodies in fFN level test of animal Dog/Canine with premature delivery.
Tag	hFc
Products description	Anti-Canine fFN human monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-fFN antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Target/Biomarker information

Canine Fetal Fibronectin (c-fFN) is a remarkable biomarker intricately woven into the tapestry of canine reproductive biology. This glycoprotein, uniquely found within the amniotic fluid and placental tissues of pregnant dogs, holds the pivotal responsibility of securing the bonds that sustain pregnancy. Structurally, c-fFN is part of the fibronectin family, a group of adhesive proteins that play crucial roles in cell adhesion and tissue organization. The primary mission of c-fFN is to serve as a molecular adhesive. During pregnancy, it acts as the glue that binds the developing canine embryos to the uterine wall. This adhesion is not merely a structural function; it is the foundation upon which the entire pregnancy relies. Without the stable connection c-fFN provides, the developing pups would be at risk of detachment from the uterine lining, leading to a host of potential complications. Beyond its adhesive properties, c-fFN plays a strategic role in immune regulation. Pregnancy represents a unique challenge for the maternal immune system, as it must tolerate the presence of semi-allogeneic embryos—offspring that share some, but not all, genetic material with the mother. c-fFN contributes to immune tolerance, ensuring that the mother's immune system does not mount a hostile response against the developing embryos. This immunomodulatory function is crucial for the success of canine pregnancies.

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