Canine cTnI antibody and antigen (recombinant protein)

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-CAN-cTnI-Ag01	Recombinant Canine cTnI protein	3090
GMP-CAN-cTnI-Ab01	Anti-Canine cTnI mouse monoclonal antibody (mAb)	3090
GMP-CAN-cTnI-Ab02	Anti-Canine cTnI mouse monoclonal antibody (mAb)	3090
GMP-CAN-cTnI-Ab03	Anti-Canine cTnI human monoclonal antibody (mAb)	3090
GMP-CAN-cTnI-Ab04	Anti-Canine cTnI human monoclonal antibody (mAb)	3090

Size： 1mg | 10mg | 100mg

Product Description

Cat No. of Products	GMP-CAN-cTnI-Ag01
Product Name	Recombinant Canine cTnI protein
Target/Biomarker	Canine Cardiac Troponin I (cTnI)
Alias of Target/Biomarker	Canine Cardiac Troponin I (cTnI)
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Canine Cardiac Troponin I antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in cTnI level test of animal Dog/Canine with Myocardial injury, heart disease.
Tag	His
Products description	Recombinant Canine cTnI protein was expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation	Supplied as a 0.2 μM filtered solution of PBS,PH7.4.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-CAN-cTnI-Ab01, GMP-CAN-cTnI-Ab02
Product Name	Anti-Canine cTnI mouse monoclonal antibody (mAb)
Target/Biomarker	Canine Cardiac Troponin I (cTnI)
Alias of Target/Biomarker	Canine Cardiac Troponin I (cTnI)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Canine Cardiac Troponin I antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-cTnI antibodies in cTnI level test of animal Dog/Canine with Myocardial injury, heart disease.
Tag	mFc
Products description	Anti-Canine cTnI mouse monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-cTnI antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation	Supplied as a 0.2 μM filtered solution of PBS,PH7.4.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-CAN-cTnI-Ab03, GMP-CAN-cTnI-Ab04
Product Name	Anti-Canine cTnI human monoclonal antibody (mAb)
Target/Biomarker	Canine Cardiac Troponin I (cTnI)
Alias of Target/Biomarker	Canine Cardiac Troponin I (cTnI)
Expression platform	CHO
Isotypes	Human IgG1
Bioactivity validation	Recombinant Canine Cardiac Troponin I antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-cTnI antibodies in cTnI level test of animal Dog/Canine with Myocardial injury, heart disease.
Tag	hFc
Products description	Anti-Canine cTnI human monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-cTnI antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation	Supplied as a 0.2 μM filtered solution of PBS,PH7.4.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Target/Biomarker information

Cardiac Troponin I (cTnI), an integral component of the troponin complex, is a cardiac-specific protein with paramount importance in the context of canine physiology. This protein is predominantly expressed in cardiac muscle cells, setting it apart as a specific biomarker for cardiac health assessment in dogs (canines). To comprehend the significance of cTnI, it is crucial to delve into its structure, function, and role in canine cardiology. Structurally, cTnI is part of the troponin complex, which includes two other subunits: cardiac Troponin T (cTnT) and cardiac Troponin C (cTnC). The troponin complex is integral to the regulation of muscle contraction in the heart. Within the sarcomeres of cardiac muscle fibers, cTnI serves as a regulatory protein that, in association with cTnT and cTnC, governs the interactions between actin and myosin, the two key proteins responsible for muscle contraction. cTnI's uniqueness lies in its cardiac specificity. While other troponin isoforms exist in skeletal muscle, cTnI is exclusively found in the heart. This exclusivity makes cTnI a highly specific biomarker for cardiac muscle injury or damage. When cardiac cells are injured due to myocardial infarction, cardiac diseases, or other factors, cTnI is released into the bloodstream. Thus, the measurement of cTnI levels in a dog's serum can provide critical diagnostic insights into myocardial health. Detection of cTnI is typically accomplished through immunoassays, such as enzyme-linked immunosorbent assays (ELISA). These assays allow for the quantitative assessment of cTnI concentration in the blood, enabling veterinarians to gauge the extent of cardiac injury or disease. The sensitivity of these assays is such that even minor cardiac damage can lead to detectable elevations in cTnI levels, facilitating early diagnosis and intervention.

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