Canine cIV antibody and antigen (recombinant protein)

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-CAN-cIV-Ag01	Recombinant Canine cIV protein	3090
GMP-CAN-cIV-Ab01	Anti-Canine cIV mouse monoclonal antibody (mAb)	1953
GMP-CAN-cIV-Ab02	Anti-Canine cIV mouse monoclonal antibody (mAb)	1953
GMP-CAN-cIV-Ab03	Anti-Canine cIV human monoclonal antibody (mAb)	1953
GMP-CAN-cIV-Ab04	Anti-Canine cIV human monoclonal antibody (mAb)	1953

Size： 1mg | 10mg | 100mg

Product Description

Cat No. of Products	GMP-CAN-cIV-Ag01
Product Name	Recombinant Canine cIV protein
Target/Biomarker	Canine collagen type IV ()
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Canine collagen type IV antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in level test of animal Dog/Canine with Goodpasture syndrome, Alport syndrome, glomerular basement membrane, Liver fibrosis and cirrhosis, alcoholic liver disease, hepatitis C and fall following successful therapy. autosomal dominant hereditary angiopathy, nephropathy, aneurysms, and muscle cramps. porencephaly, schizencephaly, congenital cataract, coronary artery disease, diabetic nephropathy and renal injury..
Tag	His
Products description	Recombinant Canine cIV protein was expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-CAN-cIV-Ab01, GMP-CAN-cIV-Ab02
Product Name	Anti-Canine cIV mouse monoclonal antibody (mAb)
Target/Biomarker	Canine collagen type IV ()
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Canine collagen type IV antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti- antibodies in level test of animal Dog/Canine with Goodpasture syndrome, Alport syndrome, glomerular basement membrane, Liver fibrosis and cirrhosis, alcoholic liver disease, hepatitis C and fall following successful therapy. autosomal dominant hereditary angiopathy, nephropathy, aneurysms, and muscle cramps. porencephaly, schizencephaly, congenital cataract, coronary artery disease, diabetic nephropathy and renal injury..
Tag	mFc
Products description	Anti-Canine cIV mouse monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti- antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-CAN-cIV-Ab03, GMP-CAN-cIV-Ab04
Product Name	Anti-Canine cIV human monoclonal antibody (mAb)
Target/Biomarker	Canine collagen type IV ()
Expression platform	CHO
Isotypes	Human IgG1
Bioactivity validation	Recombinant Canine collagen type IV antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti- antibodies in level test of animal Dog/Canine with Goodpasture syndrome, Alport syndrome, glomerular basement membrane, Liver fibrosis and cirrhosis, alcoholic liver disease, hepatitis C and fall following successful therapy. autosomal dominant hereditary angiopathy, nephropathy, aneurysms, and muscle cramps. porencephaly, schizencephaly, congenital cataract, coronary artery disease, diabetic nephropathy and renal injury..
Tag	hFc
Products description	Anti-Canine cIV human monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti- antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Target/Biomarker information

Canine Collagen Type IV (cIV) stands as an unassuming yet indispensable structural component in the intricate web of canine physiology. As a member of the collagen family, it shoulders the monumental responsibility of maintaining the integrity of basement membranes, a role that resonates throughout the canine body. Structurally, cIV is a collagen protein comprising three polypeptide chains intertwined in a triple helical structure. This unique arrangement lends both strength and flexibility to cIV, making it an ideal candidate for the rigorous task of supporting basement membranes. These membranes are the unsung heroes beneath the scenes, forming a delicate yet robust interface between cells and the surrounding extracellular matrix. Basement membranes are not merely passive barriers; they are dynamic regulators of cellular activities. cIV plays a multifaceted role within these membranes. It provides the structural framework, ensuring that basement membranes maintain their structural integrity even under mechanical stresses. Additionally, cIV interacts with various proteins and signaling molecules, contributing to the filtration properties of basement membranes and orchestrating essential cellular signaling events.

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