Canine α-defensin 5 antibody and antigen (recombinant protein)

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-CAN-a-defensin-5-Ag01	Recombinant Canine α-defensin 5 protein	3090
GMP-CAN-a-defensin-5-Ab01	Anti-Canine α-defensin 5 mouse monoclonal antibody (mAb)	1953
GMP-CAN-a-defensin-5-Ab02	Anti-Canine α-defensin 5 mouse monoclonal antibody (mAb)	1953
GMP-CAN-a-defensin-5-Ab03	Anti-Canine α-defensin 5 human monoclonal antibody (mAb)	1953
GMP-CAN-a-defensin-5-Ab04	Anti-Canine α-defensin 5 human monoclonal antibody (mAb)	1953

Size： 1mg | 10mg | 100mg

Product Description

Cat No. of Products	GMP-CAN-a-defensin-5-Ag01
Product Name	Recombinant Canine α-defensin 5 protein
Target/Biomarker	Canine alpha defensin 5 (α-defensin 5)
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Canine alpha defensin 5 antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in α-defensin 5 level test of animal Dog/Canine with Prosthetic joint infection (PJI).
Tag	His
Products description	Recombinant Canine α-defensin 5 protein was expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-CAN-a-defensin-5-Ab01, GMP-CAN-a-defensin-5-Ab02
Product Name	Anti-Canine α-defensin 5 mouse monoclonal antibody (mAb)
Target/Biomarker	Canine alpha defensin 5 (α-defensin 5)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Canine alpha defensin 5 antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-α-defensin 5 antibodies in α-defensin 5 level test of animal Dog/Canine with Prosthetic joint infection (PJI).
Tag	mFc
Products description	Anti-Canine α-defensin 5 mouse monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-α-defensin 5 antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-CAN-a-defensin-5-Ab03, GMP-CAN-a-defensin-5-Ab04
Product Name	Anti-Canine α-defensin 5 human monoclonal antibody (mAb)
Target/Biomarker	Canine alpha defensin 5 (α-defensin 5)
Expression platform	CHO
Isotypes	Human IgG1
Bioactivity validation	Recombinant Canine alpha defensin 5 antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-α-defensin 5 antibodies in α-defensin 5 level test of animal Dog/Canine with Prosthetic joint infection (PJI).
Tag	hFc
Products description	Anti-Canine α-defensin 5 human monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-α-defensin 5 antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Target/Biomarker information

α-defensin 5, or Def5, is a remarkable antimicrobial peptide found in the canine digestive system, specifically in the small intestine. It is a member of the α-defensin family, which comprises small, cationic peptides known for their potent antimicrobial properties. These peptides are pivotal components of the innate immune system, contributing significantly to the host's defense against invading pathogens. The synthesis and secretion of α-defensin 5 primarily occur within Paneth cells, specialized secretory cells located in the crypts of Lieberkühn in the small intestine. These cells are strategically positioned to defend the intestinal epithelium from harmful microorganisms. α-defensin 5 is part of this frontline defense mechanism, actively engaging and neutralizing a wide range of bacteria, viruses, and fungi that may enter the digestive tract. Structurally, α-defensin 5 possesses a unique arrangement of cysteine residues that form disulfide bonds. These bonds not only provide structural stability but also enhance its antimicrobial activity. This biomarker exhibits a remarkable ability to disrupt microbial cell membranes, leading to their lysis and subsequent elimination from the gastrointestinal tract.

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