Canine TrxR antibody and antigen (recombinant protein)

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-CAN-TrxR-Ag01	Recombinant Canine TrxR protein	3090
GMP-CAN-TrxR-Ab01	Anti-Canine TrxR mouse monoclonal antibody (mAb)	1953
GMP-CAN-TrxR-Ab02	Anti-Canine TrxR mouse monoclonal antibody (mAb)	1953
GMP-CAN-TrxR-Ab03	Anti-Canine TrxR human monoclonal antibody (mAb)	1953
GMP-CAN-TrxR-Ab04	Anti-Canine TrxR human monoclonal antibody (mAb)	1953

Size： 1mg | 10mg | 100mg

Product Description

Cat No. of Products	GMP-CAN-TrxR-Ag01
Product Name	Recombinant Canine TrxR protein
Target/Biomarker	Canine thioredoxin reductase (SCC Ag)
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Canine thioredoxin reductase antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in SCC Ag level test of animal Dog/Canine with cancer, viral disease, ischaemia– reperfusion injury, cardiac conditions, aging, premature birth.
Tag	His
Products description	Recombinant Canine TrxR protein was expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-CAN-TrxR-Ab01, GMP-CAN-TrxR-Ab02
Product Name	Anti-Canine TrxR mouse monoclonal antibody (mAb)
Target/Biomarker	Canine thioredoxin reductase (SCC Ag)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Canine thioredoxin reductase antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-SCC Ag antibodies in SCC Ag level test of animal Dog/Canine with cancer, viral disease, ischaemia– reperfusion injury, cardiac conditions, aging, premature birth.
Tag	mFc
Products description	Anti-Canine TrxR mouse monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-SCC Ag antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-CAN-TrxR-Ab03, GMP-CAN-TrxR-Ab04
Product Name	Anti-Canine TrxR human monoclonal antibody (mAb)
Target/Biomarker	Canine thioredoxin reductase (SCC Ag)
Expression platform	CHO
Isotypes	Human IgG1
Bioactivity validation	Recombinant Canine thioredoxin reductase antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-SCC Ag antibodies in SCC Ag level test of animal Dog/Canine with cancer, viral disease, ischaemia– reperfusion injury, cardiac conditions, aging, premature birth.
Tag	hFc
Products description	Anti-Canine TrxR human monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-SCC Ag antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Target/Biomarker information

Canine Thioredoxin Reductase (TrxR) is an enzyme that takes center stage in the intricate theater of canine cellular biochemistry. It is a sentinel in the battle against oxidative stress, a relentless antagonist that can jeopardize the well-being of dogs at a cellular level. Structurally and functionally akin to its counterparts in other species, TrxR in dogs plays a fundamental role in safeguarding cellular components from the perils of reactive oxygen species (ROS). The story of TrxR unfolds within the confines of dog cells, where it orchestrates a complex dance of redox reactions. At its core, TrxR catalyzes the reduction of thioredoxin (Trx), a diminutive yet influential protein that serves as a guardian of redox balance. In its reduced form, Trx stands ready to neutralize ROS, effectively diffusing the potential for oxidative damage to critical cellular components. Canine physiology is no stranger to the continuous production of ROS. These molecules, born as byproducts of normal cellular metabolism, carry the potential for cellular chaos when their levels surge beyond the capacity of antioxidant defenses. Here, TrxR emerges as a defender, ensuring that the balance is maintained and oxidative stress is kept at bay. When ROS production escalates due to external stressors, aging, or disease processes, TrxR becomes all the more critical. Its activity level becomes a gauge of a dog's resilience against oxidative damage. Low TrxR activity implies a diminished capacity to cope with ROS onslaught, rendering dogs vulnerable to oxidative stress-related afflictions. Dogs, like all organisms, face the consequences of oxidative stress in various forms. From inflammation-driven conditions to the wear and tear of aging, the impact of oxidative damage can be far-reaching. Monitoring TrxR levels provides an opportunity for proactive intervention. By understanding a dog's antioxidant capacity, veterinarians and caregivers can tailor strategies to bolster this defense system, ensuring a higher quality of life and longevity for our canine companions.

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