Canine TSH antibody and antigen (recombinant protein)

Diagnostic anti-Canine TSH antibodies pairs and antigen for animal health (animal Dog/Canine Hypothyroidism, hyperthyroidism) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

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Product information

Catalog No. Description US $ Price (per mg)
GMP-CAN-TSH-Ag01 Recombinant Canine TSH protein 3090
GMP-CAN-TSH-Ab01 Anti-Canine TSH mouse monoclonal antibody (mAb) 1953
GMP-CAN-TSH-Ab02 Anti-Canine TSH mouse monoclonal antibody (mAb) 1953
GMP-CAN-TSH-Ab03 Anti-Canine TSH human monoclonal antibody (mAb) 1953
GMP-CAN-TSH-Ab04 Anti-Canine TSH human monoclonal antibody (mAb) 1953

Size: 1mg | 10mg | 100mg



Product Description

Cat No. of Products GMP-CAN-TSH-Ag01
Product Name Recombinant Canine TSH protein
Target/Biomarker Canine Thyroid Stimulating Hormone (SAA)
Expression platform E.coli
Isotypes Recombinant Antigen
Bioactivity validation Anti-Canine Thyroid Stimulating Hormone antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in SAA level test of animal Dog/Canine with Hypothyroidism, hyperthyroidism.
Tag His
Products description Recombinant Canine TSH protein was expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity Purity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products GMP-CAN-TSH-Ab01, GMP-CAN-TSH-Ab02
Product Name Anti-Canine TSH mouse monoclonal antibody (mAb)
Target/Biomarker Canine Thyroid Stimulating Hormone (SAA)
Expression platform CHO
Isotypes Mouse IgG
Bioactivity validation Recombinant Canine Thyroid Stimulating Hormone antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-SAA antibodies in SAA level test of animal Dog/Canine with Hypothyroidism, hyperthyroidism.
Tag mFc
Products description Anti-Canine TSH mouse monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-SAA antibodies.
Purity Purity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products GMP-CAN-TSH-Ab03, GMP-CAN-TSH-Ab04
Product Name Anti-Canine TSH human monoclonal antibody (mAb)
Target/Biomarker Canine Thyroid Stimulating Hormone (SAA)
Expression platform CHO
Isotypes Human IgG1
Bioactivity validation Recombinant Canine Thyroid Stimulating Hormone antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-SAA antibodies in SAA level test of animal Dog/Canine with Hypothyroidism, hyperthyroidism.
Tag hFc
Products description Anti-Canine TSH human monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-SAA antibodies.
Purity Purity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Validation Data


    Click to get more Data / Case study about the product.



    Target/Biomarker information

    Thyroid-Stimulating Hormone (TSH) is a master regulator of thyroid gland activity in dogs, exerting a profound influence on their metabolic well-being. This glycoprotein hormone is at the core of the intricate network known as the hypothalamic-pituitary-thyroid (HPT) axis. Produced and secreted by the anterior pituitary gland in response to fluctuations in thyroid hormone levels, TSH plays a pivotal role in maintaining thyroid homeostasis. Structurally, TSH is a heterodimeric glycoprotein consisting of alpha and beta subunits. Its production is triggered by a sensor system within the hypothalamus-pituitary complex, specifically the hypothalamus's release of thyrotropin-releasing hormone (TRH) and the subsequent secretion of thyroid-releasing hormone (TRH). Low levels of thyroid hormones (triiodothyronine or T3 and thyroxine or T4) in the bloodstream serve as the primary stimulants for TSH release. Once released, TSH travels via the bloodstream to the thyroid gland, where it binds to specific receptors on the thyroid follicular cells. This binding event triggers a cascade of intracellular processes that culminate in increased thyroid hormone production and secretion. TSH acts as the conductor of the thyroid orchestra, orchestrating the synthesis and release of T3 and T4 to meet the metabolic demands of the dog's body. The importance of TSH in canine physiology cannot be overstated. It ensures that the metabolic rate is finely tuned to meet the body's energy needs. During periods of increased metabolic demands, such as growth, pregnancy, or exposure to cold temperatures, TSH rises to stimulate greater thyroid hormone production, thereby ramping up the metabolic furnace. Conversely, when metabolic needs diminish, TSH levels decrease, conserving energy resources.



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