Canine TIMP-1 antibody and antigen (recombinant protein)

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-CAN-TIMP-1-Ag01	Recombinant Canine TIMP-1 protein	3090
GMP-CAN-TIMP-1-Ab01	Anti-Canine TIMP-1 mouse monoclonal antibody (mAb)	1953
GMP-CAN-TIMP-1-Ab02	Anti-Canine TIMP-1 mouse monoclonal antibody (mAb)	1953
GMP-CAN-TIMP-1-Ab03	Anti-Canine TIMP-1 human monoclonal antibody (mAb)	1953
GMP-CAN-TIMP-1-Ab04	Anti-Canine TIMP-1 human monoclonal antibody (mAb)	1953

Size： 1mg | 10mg | 100mg

Product Description

Cat No. of Products	GMP-CAN-TIMP-1-Ag01
Product Name	Recombinant Canine TIMP-1 protein
Target/Biomarker	Canine Matrix Metalloproteinase Inhibitor-1 (S100-A8)
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Canine Matrix Metalloproteinase Inhibitor-1 antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in S100-A8 level test of animal Dog/Canine with coronary artery stenosis, coronary artery lesions.
Tag	His
Products description	Recombinant Canine TIMP-1 protein was expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-CAN-TIMP-1-Ab01, GMP-CAN-TIMP-1-Ab02
Product Name	Anti-Canine TIMP-1 mouse monoclonal antibody (mAb)
Target/Biomarker	Canine Matrix Metalloproteinase Inhibitor-1 (S100-A8)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Canine Matrix Metalloproteinase Inhibitor-1 antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-S100-A8 antibodies in S100-A8 level test of animal Dog/Canine with coronary artery stenosis, coronary artery lesions.
Tag	mFc
Products description	Anti-Canine TIMP-1 mouse monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-S100-A8 antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-CAN-TIMP-1-Ab03, GMP-CAN-TIMP-1-Ab04
Product Name	Anti-Canine TIMP-1 human monoclonal antibody (mAb)
Target/Biomarker	Canine Matrix Metalloproteinase Inhibitor-1 (S100-A8)
Expression platform	CHO
Isotypes	Human IgG1
Bioactivity validation	Recombinant Canine Matrix Metalloproteinase Inhibitor-1 antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-S100-A8 antibodies in S100-A8 level test of animal Dog/Canine with coronary artery stenosis, coronary artery lesions.
Tag	hFc
Products description	Anti-Canine TIMP-1 human monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-S100-A8 antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Target/Biomarker information

Tissue inhibitor of metalloproteinase-1 (TIMP-1) is a member of the TIMP family, which comprises four structurally related proteins that are known to regulate the activity of matrix metalloproteinases (MMPs). MMPs are zinc-dependent endopeptidases that are involved in the degradation of extracellular matrix (ECM) components, such as collagen, elastin, and proteoglycans. The balance between MMP activity and TIMPs is critical for ECM remodeling, tissue repair, and angiogenesis. TIMP-1 is a secreted glycoprotein that is synthesized by various cells and tissues in animals, including canines/dogs. TIMP-1 has been shown to bind to the active site of MMPs, inhibiting their activity and preventing excessive ECM degradation. In addition to MMP inhibition, TIMP-1 has been shown to have MMP-independent functions, including promoting cell proliferation, differentiation, and apoptosis, as well as modulating immune responses, angiogenesis, and tissue repair processes. TIMP-1 expression is regulated by various cellular processes, including growth factors, cytokines, and ECM components. Its expression has been detected in various cells and tissues in animals, including fibroblasts, endothelial cells, epithelial cells, and macrophages.

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