Canine TG antibody and antigen (recombinant protein)

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-CAN-TG-Ag01	Recombinant Canine TG protein	3090
GMP-CAN-TG-Ab01	Anti-Canine TG mouse monoclonal antibody (mAb)	1953
GMP-CAN-TG-Ab02	Anti-Canine TG mouse monoclonal antibody (mAb)	1953
GMP-CAN-TG-Ab03	Anti-Canine TG human monoclonal antibody (mAb)	1953
GMP-CAN-TG-Ab04	Anti-Canine TG human monoclonal antibody (mAb)	1953

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Product Description

Cat No. of Products	GMP-CAN-TG-Ag01
Product Name	Recombinant Canine TG protein
Target/Biomarker	Canine Thyroglobulin (RLN)
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Canine Thyroglobulin antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in RLN level test of animal Dog/Canine with thyroid nodules, thyroid adenomas, multinodular goiters, thyrotoxicosis, thyroid cancer.
Tag	His
Products description	Recombinant Canine TG protein was expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-CAN-TG-Ab01, GMP-CAN-TG-Ab02
Product Name	Anti-Canine TG mouse monoclonal antibody (mAb)
Target/Biomarker	Canine Thyroglobulin (RLN)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Canine Thyroglobulin antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-RLN antibodies in RLN level test of animal Dog/Canine with thyroid nodules, thyroid adenomas, multinodular goiters, thyrotoxicosis, thyroid cancer.
Tag	mFc
Products description	Anti-Canine TG mouse monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-RLN antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-CAN-TG-Ab03, GMP-CAN-TG-Ab04
Product Name	Anti-Canine TG human monoclonal antibody (mAb)
Target/Biomarker	Canine Thyroglobulin (RLN)
Expression platform	CHO
Isotypes	Human IgG1
Bioactivity validation	Recombinant Canine Thyroglobulin antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-RLN antibodies in RLN level test of animal Dog/Canine with thyroid nodules, thyroid adenomas, multinodular goiters, thyrotoxicosis, thyroid cancer.
Tag	hFc
Products description	Anti-Canine TG human monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-RLN antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Target/Biomarker information

In dogs (canines), "TG" typically refers to triglycerides, which are a type of fat (lipid) found in the blood. Triglycerides are derived from the fats eaten in foods or are made in the body from other energy sources, such as carbohydrates. When a dog eats, any calories it doesn't need to use immediately are converted into triglycerides and stored in fat cells. Hormones later release triglycerides for energy between meals. Importance of Triglycerides in Dogs Triglycerides serve as a major source of energy for the body, but high levels of triglycerides in the blood (hypertriglyceridemia) can be a marker for various health issues in dogs, including: Pancreatitis: This is an inflammation of the pancreas that can be acute or chronic. High triglyceride levels are a risk factor for the development of pancreatitis in dogs. Obesity: Elevated triglyceride levels are often seen in obese dogs, which can predispose them to other health conditions such as diabetes mellitus, cardiovascular disease, and joint problems. Diabetes Mellitus: Dogs with diabetes may have high triglyceride levels due to the altered metabolism associated with insulin deficiency or resistance. Hypothyroidism: This condition, caused by an underactive thyroid gland, can lead to elevated triglyceride levels as part of a broader spectrum of metabolic disturbances. Cushing’s Disease (Hyperadrenocorticism): This endocrine disorder can cause a variety of symptoms, including increased triglyceride levels. Diagnosis and Monitoring Blood Tests: The diagnosis of high triglyceride levels is made through blood tests, which measure the lipid profile of the dog. It's important for dogs to fast for 8-12 hours before a lipid profile test to get accurate measurements of triglyceride levels. Monitoring: Dogs with known risk factors for high triglycerides, such as those with obesity, diabetes, or pancreatitis, should have their levels monitored regularly as part of their health management plan. Treatment and Management Dietary Management: Often, the first step in managing high triglyceride levels is through dietary changes. Diets low in fat and high in fiber can help manage triglyceride levels. Weight Management: For obese dogs, weight loss can help lower triglyceride levels and reduce the risk of associated diseases. Medication: In some cases, medication may be necessary to manage underlying conditions contributing to high triglyceride levels, such as hypothyroidism or diabetes. Regular Exercise: Regular physical activity can help manage weight and lower triglycerides. Prevention Preventive measures include maintaining a healthy diet and weight, regular exercise, and routine veterinary check-ups to identify and manage any underlying health issues before they lead to elevated triglyceride levels. In summary, while triglycerides play a crucial role in providing energy for dogs, monitoring and managing their levels is important for preventing and managing various health conditions. Regular veterinary care is essential to maintaining the health and well-being of dogs, particularly those at risk for high triglyceride levels.

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