Canine Spirochaeta antibody and antigen (recombinant protein)

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-CAN-Spirochaeta-Ag01	Recombinant Canine Spirochaeta protein	3090
GMP-CAN-Spirochaeta-Ab01	Anti-Canine Spirochaeta mouse monoclonal antibody (mAb)	1953
GMP-CAN-Spirochaeta-Ab02	Anti-Canine Spirochaeta mouse monoclonal antibody (mAb)	1953
GMP-CAN-Spirochaeta-Ab03	Anti-Canine Spirochaeta human monoclonal antibody (mAb)	1953
GMP-CAN-Spirochaeta-Ab04	Anti-Canine Spirochaeta human monoclonal antibody (mAb)	1953

Size： 1mg | 10mg | 100mg

Product Description

Cat No. of Products	GMP-CAN-Spirochaeta-Ag01
Product Name	Recombinant Canine Spirochaeta protein
Target/Biomarker	Canine Spirochaeta ()
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Canine Spirochaeta antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in level test of animal Dog/Canine with N/A.
Tag	His
Products description	Recombinant Canine Spirochaeta protein was expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-CAN-Spirochaeta-Ab01, GMP-CAN-Spirochaeta-Ab02
Product Name	Anti-Canine Spirochaeta mouse monoclonal antibody (mAb)
Target/Biomarker	Canine Spirochaeta ()
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Canine Spirochaeta antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti- antibodies in level test of animal Dog/Canine with N/A.
Tag	mFc
Products description	Anti-Canine Spirochaeta mouse monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti- antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-CAN-Spirochaeta-Ab03, GMP-CAN-Spirochaeta-Ab04
Product Name	Anti-Canine Spirochaeta human monoclonal antibody (mAb)
Target/Biomarker	Canine Spirochaeta ()
Expression platform	CHO
Isotypes	Human IgG1
Bioactivity validation	Recombinant Canine Spirochaeta antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti- antibodies in level test of animal Dog/Canine with N/A.
Tag	hFc
Products description	Anti-Canine Spirochaeta human monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti- antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Target/Biomarker information

In dogs (canines), the term "Spirochaeta" refers to bacteria from the phylum Spirochaetes, which are characterized by their unique spiral shape and distinctive method of movement. These bacteria can cause a variety of diseases in dogs, with some of the most notable being caused by specific genera such as Leptospira, Borrelia, and Treponema. Here’s an overview of the diseases associated with these spirochetes in dogs: Leptospirosis Cause: Caused by bacteria from the genus Leptospira, leptospirosis is a significant concern in canine health. It is a zoonotic disease, meaning it can be transmitted from animals to humans. Transmission: Dogs can contract the bacteria from contaminated water sources, soil, or through direct contact with the urine of infected animals. Symptoms: Can range from mild to severe and include fever, vomiting, abdominal pain, diarrhea, refusal to eat, severe weakness and lethargy, stiffness, jaundice, muscle pain, infertility, and kidney or liver failure. Treatment: Involves antibiotics and supportive care. Early diagnosis and treatment are crucial for recovery. Prevention: Vaccination against certain strains of Leptospira is available and recommended, especially in areas where the disease is common. Lyme Disease Cause: Caused by the bacterium Borrelia burgdorferi, transmitted to dogs through the bite of infected Ixodes ticks (deer ticks). Symptoms: Include fever, lameness due to inflammation of the joints, swollen lymph nodes, lethargy, and loss of appetite. Not all infected dogs will show symptoms. Treatment: Typically involves antibiotics like doxycycline. Early treatment usually results in rapid improvement. Prevention: Preventative measures include tick control products and vaccines against Lyme disease, along with regular tick checks. Canine Spirochetosis (Periodontal Disease) Cause: Spirochetes, including members of the genus Treponema, have been implicated in periodontal disease in dogs, contributing to gum infection and tooth decay. Symptoms: Bad breath, plaque build-up, inflamed gums, and tooth loss. It can lead to more serious health issues if bacteria enter the bloodstream. Treatment: Includes professional dental cleaning and may require tooth extractions or other periodontal treatments. Prevention: Regular dental care, including brushing the dog's teeth and using dental chews, along with professional cleanings, can help prevent periodontal disease. Diagnosis and Treatment Diagnosis of spirochetal infections generally involves serological testing, PCR assays, microscopic examination, and sometimes culture of the organism. Treatment varies depending on the disease but often includes the use of specific antibiotics effective against spirochetes, supportive care for symptoms, and preventive measures to avoid exposure to the pathogens. Prevention Vaccination against leptospirosis and Lyme disease is available and recommended in areas where these diseases are prevalent. Tick Control is crucial for preventing Lyme disease and other tick-borne illnesses. Environmental Management and hygiene can help reduce the risk of leptospirosis by avoiding stagnant water and controlling rodent populations. Dental Care is essential for preventing periodontal disease caused by spirochetes among other bacteria. Spirochetal infections in dogs can be serious but are often manageable with prompt veterinary care. Prevention through vaccination, tick control, and good hygiene practices is key to keeping dogs healthy and reducing the risk of these infections.

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