Canine S100-A8 antibody and antigen (recombinant protein)

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-CAN-S100-A8-Ag01	Recombinant Canine S100-A8 protein	3090
GMP-CAN-S100-A8-Ab01	Anti-Canine S100-A8 mouse monoclonal antibody (mAb)	1953
GMP-CAN-S100-A8-Ab02	Anti-Canine S100-A8 mouse monoclonal antibody (mAb)	1953
GMP-CAN-S100-A8-Ab03	Anti-Canine S100-A8 human monoclonal antibody (mAb)	1953
GMP-CAN-S100-A8-Ab04	Anti-Canine S100-A8 human monoclonal antibody (mAb)	1953

Size： 1mg | 10mg | 100mg

Product Description

Cat No. of Products	GMP-CAN-S100-A8-Ag01
Product Name	Recombinant Canine S100-A8 protein
Target/Biomarker	Canine Calprotectin (S100-A8)
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Canine Calprotectin antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in S100-A8 level test of animal Dog/Canine with intestinal inflammation.
Tag	His
Products description	Recombinant Canine S100-A8 protein was expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-CAN-S100-A8-Ab01, GMP-CAN-S100-A8-Ab02
Product Name	Anti-Canine S100-A8 mouse monoclonal antibody (mAb)
Target/Biomarker	Canine Calprotectin (S100-A8)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Canine Calprotectin antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-S100-A8 antibodies in S100-A8 level test of animal Dog/Canine with intestinal inflammation.
Tag	mFc
Products description	Anti-Canine S100-A8 mouse monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-S100-A8 antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-CAN-S100-A8-Ab03, GMP-CAN-S100-A8-Ab04
Product Name	Anti-Canine S100-A8 human monoclonal antibody (mAb)
Target/Biomarker	Canine Calprotectin (S100-A8)
Expression platform	CHO
Isotypes	Human IgG1
Bioactivity validation	Recombinant Canine Calprotectin antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-S100-A8 antibodies in S100-A8 level test of animal Dog/Canine with intestinal inflammation.
Tag	hFc
Products description	Anti-Canine S100-A8 human monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-S100-A8 antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Target/Biomarker information

Canine S100-A8, also known as Calgranulin A, stands as a linchpin in the intricate web of the canine immune system. This protein, belonging to the S100 family, is characterized by its calcium-binding properties and its profound influence on immune responses in dogs. Structurally, Canine S100-A8 exists as a dimeric protein, composed of two subunits, each featuring two calcium-binding EF-hand motifs. While it is primarily located within immune cells, particularly neutrophils and monocytes, it also has a presence in non-immune cells, underscoring its versatile role in modulating immune functions and inflammation. Upon activation of immune cells, Canine S100-A8 can be secreted into the extracellular environment, where it assumes a multifaceted role in immune regulation. It acts as a signaling molecule, communicating with other immune cells and tissues, and orchestrates an array of immune responses. One of its primary functions lies in regulating inflammation. Canine S100-A8 serves as a potent proinflammatory mediator, aiding in the recruitment of immune cells to sites of infection or tissue injury. It acts as a chemoattractant, guiding immune cells to the precise locations where their actions are needed. Furthermore, it plays a role in the phagocytosis of pathogens, assisting in the clearance of microbial invaders. Beyond its proinflammatory functions, Canine S100-A8 is also implicated in tissue repair and regeneration processes. It participates in the restoration of damaged tissues following immune responses, contributing to the resolution of inflammation and the return to normal tissue function.

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