Canine Proinsulin antibody and antigen (recombinant protein)

 Download 

Product information

Catalog No.	Description	US $ Price (per mg)
GMP-CAN-Proinsulin-Ag01	Recombinant Canine Proinsulin protein	3090
GMP-CAN-Proinsulin-Ab01	Anti-Canine Proinsulin mouse monoclonal antibody (mAb)	1953
GMP-CAN-Proinsulin-Ab02	Anti-Canine Proinsulin mouse monoclonal antibody (mAb)	1953
GMP-CAN-Proinsulin-Ab03	Anti-Canine Proinsulin human monoclonal antibody (mAb)	1953
GMP-CAN-Proinsulin-Ab04	Anti-Canine Proinsulin human monoclonal antibody (mAb)	1953

Size： 1mg | 10mg | 100mg

Product Description

Cat No. of Products	GMP-CAN-Proinsulin-Ag01
Product Name	Recombinant Canine Proinsulin protein
Target/Biomarker	Canine Proinsulin ()
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Canine Proinsulin antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in level test of animal Dog/Canine with type 2 diabetes.
Tag	His
Products description	Recombinant Canine Proinsulin protein was expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-CAN-Proinsulin-Ab01, GMP-CAN-Proinsulin-Ab02
Product Name	Anti-Canine Proinsulin mouse monoclonal antibody (mAb)
Target/Biomarker	Canine Proinsulin ()
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Canine Proinsulin antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti- antibodies in level test of animal Dog/Canine with type 2 diabetes.
Tag	mFc
Products description	Anti-Canine Proinsulin mouse monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti- antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-CAN-Proinsulin-Ab03, GMP-CAN-Proinsulin-Ab04
Product Name	Anti-Canine Proinsulin human monoclonal antibody (mAb)
Target/Biomarker	Canine Proinsulin ()
Expression platform	CHO
Isotypes	Human IgG1
Bioactivity validation	Recombinant Canine Proinsulin antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti- antibodies in level test of animal Dog/Canine with type 2 diabetes.
Tag	hFc
Products description	Anti-Canine Proinsulin human monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti- antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

Click to get more Data / Case study about the product.

Target/Biomarker information

Canine Proinsulin, an 81-amino acid peptide, serves as a critical intermediate in the intricate cascade of events that culminate in the production of insulin, the hormone responsible for glucose regulation in dogs. It is synthesized and secreted by the beta cells nestled within the pancreatic islets of Langerhans, marking the initial steps in insulin biosynthesis. The journey of Canine Proinsulin begins with the synthesis of preproinsulin, a longer precursor molecule. Preproinsulin subsequently undergoes a remarkable transformation, folding into proinsulin, a molecule that consists of three distinct regions: the A chain, B chain, and a connecting peptide known as the C-peptide. Notably, it is this C-peptide that distinguishes proinsulin from mature insulin. During proinsulin processing, a series of specific enzymes operate with precision to cleave the C-peptide from proinsulin. This cleavage event marks a critical transition, as it transforms proinsulin into the active insulin molecule. The newly formed insulin is then released into circulation, where it acts as a potent regulator of glucose metabolism. The presence of the C-peptide within proinsulin is more than a mere structural element; it serves a physiological purpose. The C-peptide exerts beneficial effects on blood vessel health and may possess independent actions on glucose regulation. While it does not have the same glucose-lowering properties as insulin, its measurement has garnered interest in both clinical and research settings.

About GDU