Canine PTH antibody and antigen (recombinant protein)

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-CAN-PTH-Ag01	Recombinant Canine PTH protein	3090
GMP-CAN-PTH-Ab01	Anti-Canine PTH mouse monoclonal antibody (mAb)	1953
GMP-CAN-PTH-Ab02	Anti-Canine PTH mouse monoclonal antibody (mAb)	1953
GMP-CAN-PTH-Ab03	Anti-Canine PTH human monoclonal antibody (mAb)	1953
GMP-CAN-PTH-Ab04	Anti-Canine PTH human monoclonal antibody (mAb)	1953

Size： 1mg | 10mg | 100mg

Product Description

Cat No. of Products	GMP-CAN-PTH-Ag01
Product Name	Recombinant Canine PTH protein
Target/Biomarker	Canine parathyroid hormone (PTH)
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Canine parathyroid hormone antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in PTH level test of animal Dog/Canine with Hyperparathyroidism.
Tag	His
Products description	Recombinant Canine PTH protein was expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-CAN-PTH-Ab01, GMP-CAN-PTH-Ab02
Product Name	Anti-Canine PTH mouse monoclonal antibody (mAb)
Target/Biomarker	Canine parathyroid hormone (PTH)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Canine parathyroid hormone antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-PTH antibodies in PTH level test of animal Dog/Canine with Hyperparathyroidism.
Tag	mFc
Products description	Anti-Canine PTH mouse monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-PTH antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-CAN-PTH-Ab03, GMP-CAN-PTH-Ab04
Product Name	Anti-Canine PTH human monoclonal antibody (mAb)
Target/Biomarker	Canine parathyroid hormone (PTH)
Expression platform	CHO
Isotypes	Human IgG1
Bioactivity validation	Recombinant Canine parathyroid hormone antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-PTH antibodies in PTH level test of animal Dog/Canine with Hyperparathyroidism.
Tag	hFc
Products description	Anti-Canine PTH human monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-PTH antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Target/Biomarker information

Canine Parathyroid Hormone (cPTH) is a master regulator of calcium and phosphate homeostasis in dogs, a hormone that orchestrates a delicate symphony within the body to ensure the vital functions of these minerals. Structurally, cPTH is a single-chain polypeptide hormone composed of 84 amino acids. Its genesis primarily occurs within the parathyroid glands, small, pea-sized structures located near the thyroid gland. The fundamental role of cPTH revolves around maintaining ionized calcium levels within a narrow physiological range. When blood calcium levels dip below the optimal range, the parathyroid glands are primed to take action. These glands harbor specialized calcium-sensing receptors, which, upon detecting low calcium, trigger the release of cPTH into the bloodstream. Once released, cPTH embarks on its mission to restore calcium balance by acting on multiple target organs. Its primary target is bone, where it exerts its influence by stimulating osteoclasts—cells responsible for bone resorption. This process releases calcium stored within the bone matrix into the bloodstream. Simultaneously, cPTH influences the kidneys, encouraging the reabsorption of calcium from the urine, effectively reducing calcium loss. However, cPTH's involvement doesn't end there. It also plays a pivotal role in the gut, indirectly regulating calcium absorption from dietary sources. It achieves this by prompting the production of calcitriol, the active form of vitamin D, which, in turn, enhances the uptake of dietary calcium in the intestines.

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