Canine PINP antibody and antigen (recombinant protein)

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-CAN-PINP-Ag01	Recombinant Canine PINP protein	3090
GMP-CAN-PINP-Ab01	Anti-Canine PINP mouse monoclonal antibody (mAb)	1953
GMP-CAN-PINP-Ab02	Anti-Canine PINP mouse monoclonal antibody (mAb)	1953
GMP-CAN-PINP-Ab03	Anti-Canine PINP human monoclonal antibody (mAb)	1953
GMP-CAN-PINP-Ab04	Anti-Canine PINP human monoclonal antibody (mAb)	1953

Size： 1mg | 10mg | 100mg

Product Description

Cat No. of Products	GMP-CAN-PINP-Ag01
Product Name	Recombinant Canine PINP protein
Target/Biomarker	Canine amino-terminal propeptide (PINP)
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Canine amino-terminal propeptide antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in PINP level test of animal Dog/Canine with osteoporosis therapy.
Tag	His
Products description	Recombinant Canine PINP protein was expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-CAN-PINP-Ab01, GMP-CAN-PINP-Ab02
Product Name	Anti-Canine PINP mouse monoclonal antibody (mAb)
Target/Biomarker	Canine amino-terminal propeptide (PINP)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Canine amino-terminal propeptide antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-PINP antibodies in PINP level test of animal Dog/Canine with osteoporosis therapy.
Tag	mFc
Products description	Anti-Canine PINP mouse monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-PINP antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-CAN-PINP-Ab03, GMP-CAN-PINP-Ab04
Product Name	Anti-Canine PINP human monoclonal antibody (mAb)
Target/Biomarker	Canine amino-terminal propeptide (PINP)
Expression platform	CHO
Isotypes	Human IgG1
Bioactivity validation	Recombinant Canine amino-terminal propeptide antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-PINP antibodies in PINP level test of animal Dog/Canine with osteoporosis therapy.
Tag	hFc
Products description	Anti-Canine PINP human monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-PINP antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Target/Biomarker information

Canine Procollagen Type I N-Terminal Propeptide (Canine PINP) serves as a biological window into the intricate world of canine bone health. Comprising 244 amino acids, this biomarker is a fragment of procollagen, the precursor to collagen—the structural protein that forms the foundation of bones, tendons, ligaments, and various connective tissues in dogs. Within the physiological ballet of collagen production, Canine PINP emerges as a significant player. During the formation of collagen, procollagen molecules undergo a meticulous transformation, including enzymatic cleavage. Canine PINP is released as a byproduct of this process and enters the bloodstream. It becomes a messenger, conveying information about bone turnover, collagen synthesis, and the dynamic balance that maintains skeletal integrity. Canine PINP is essential for understanding the dynamics of bone remodeling in dogs. Bones are not static structures but are in a constant state of renewal and adaptation. Elevated levels of Canine PINP may signify heightened bone turnover, suggesting a state of rapid bone resorption and formation. In young dogs, this can be indicative of healthy growth, while in older dogs, it might raise concerns about osteoporosis or underlying metabolic conditions. Conversely, decreased Canine PINP levels may point to reduced collagen synthesis and impaired bone health. Conditions like osteoarthritis may be associated with such alterations in Canine PINP levels, reflecting the gradual wear and tear on joint cartilage and bone tissue. The measurement of Canine PINP involves a simple blood test, making it a practical tool in veterinary medicine. Veterinarians rely on Canine PINP assessments to diagnose bone-related disorders and evaluate the efficacy of interventions. For example, in cases of osteoporosis, elevated Canine PINP levels may trigger therapeutic measures to support bone health. These measures may include dietary modifications to ensure an adequate intake of calcium and vitamin D or medication to enhance bone density.

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