Canine PG II antibody and antigen (recombinant protein)

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-CAN-PG-II-Ag01	Recombinant Canine PG II protein	3090
GMP-CAN-PG-II-Ab01	Anti-Canine PG II mouse monoclonal antibody (mAb)	1953
GMP-CAN-PG-II-Ab02	Anti-Canine PG II mouse monoclonal antibody (mAb)	1953
GMP-CAN-PG-II-Ab03	Anti-Canine PG II human monoclonal antibody (mAb)	1953
GMP-CAN-PG-II-Ab04	Anti-Canine PG II human monoclonal antibody (mAb)	1953

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Product Description

Cat No. of Products	GMP-CAN-PG-II-Ag01
Product Name	Recombinant Canine PG II protein
Target/Biomarker	Canine Pepsinogen II (PG II)
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Canine Pepsinogen II antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in PG II level test of animal Dog/Canine with pernicious anemia.
Tag	His
Products description	Recombinant Canine PG II protein was expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-CAN-PG-II-Ab01, GMP-CAN-PG-II-Ab02
Product Name	Anti-Canine PG II mouse monoclonal antibody (mAb)
Target/Biomarker	Canine Pepsinogen II (PG II)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Canine Pepsinogen II antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-PG II antibodies in PG II level test of animal Dog/Canine with pernicious anemia.
Tag	mFc
Products description	Anti-Canine PG II mouse monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-PG II antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-CAN-PG-II-Ab03, GMP-CAN-PG-II-Ab04
Product Name	Anti-Canine PG II human monoclonal antibody (mAb)
Target/Biomarker	Canine Pepsinogen II (PG II)
Expression platform	CHO
Isotypes	Human IgG1
Bioactivity validation	Recombinant Canine Pepsinogen II antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-PG II antibodies in PG II level test of animal Dog/Canine with pernicious anemia.
Tag	hFc
Products description	Anti-Canine PG II human monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-PG II antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Target/Biomarker information

Dog/Canine Pepsinogen II (PG II) emerges as a captivating biomarker, offering profound insights into the intricacies of canine digestion. Structurally, PG II is an inactive zymogen, a precursor to the active enzyme pepsin, and it takes center stage within the gastric mucosa of the dog's stomach. This biomolecule is primarily produced and secreted by chief cells, specialized secretory cells nestled within the gastric glands. The journey of PG II begins with the ingestion of food. As dietary proteins enter the canine stomach, PG II stands poised for its transformation into active pepsin. This metamorphosis unfolds within the acidic milieu of the gastric lumen, catalyzed by the low pH. The conversion of PG II to pepsin signifies the commencement of protein digestion, a pivotal process for nutrient absorption and overall canine health. Beyond its role as a digestive precursor, PG II serves as a barometer for gastric health. The integrity of the gastric mucosa, where PG II is predominantly localized, is crucial for proper PG II secretion. Disruptions in this mucosal lining, such as those seen in gastritis, gastric ulcers, or inflammatory bowel disease, can alter PG II levels, offering valuable diagnostic insights.

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