Canine PG I antibody and antigen (recombinant protein)

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-CAN-PG-I-Ag01	Recombinant Canine PG I protein	3090
GMP-CAN-PG-I-Ab01	Anti-Canine PG I mouse monoclonal antibody (mAb)	1953
GMP-CAN-PG-I-Ab02	Anti-Canine PG I mouse monoclonal antibody (mAb)	1953
GMP-CAN-PG-I-Ab03	Anti-Canine PG I human monoclonal antibody (mAb)	1953
GMP-CAN-PG-I-Ab04	Anti-Canine PG I human monoclonal antibody (mAb)	1953

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Product Description

Cat No. of Products	GMP-CAN-PG-I-Ag01
Product Name	Recombinant Canine PG I protein
Target/Biomarker	Canine pepsinogen I (PG I)
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Canine pepsinogen I antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in PG I level test of animal Dog/Canine with atrophic gastritis, pernicious anemia, intestinal metaplasia, dysplasia, gastric polyps, and gastric cancer.
Tag	His
Products description	Recombinant Canine PG I protein was expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-CAN-PG-I-Ab01, GMP-CAN-PG-I-Ab02
Product Name	Anti-Canine PG I mouse monoclonal antibody (mAb)
Target/Biomarker	Canine pepsinogen I (PG I)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Canine pepsinogen I antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-PG I antibodies in PG I level test of animal Dog/Canine with atrophic gastritis, pernicious anemia, intestinal metaplasia, dysplasia, gastric polyps, and gastric cancer.
Tag	mFc
Products description	Anti-Canine PG I mouse monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-PG I antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-CAN-PG-I-Ab03, GMP-CAN-PG-I-Ab04
Product Name	Anti-Canine PG I human monoclonal antibody (mAb)
Target/Biomarker	Canine pepsinogen I (PG I)
Expression platform	CHO
Isotypes	Human IgG1
Bioactivity validation	Recombinant Canine pepsinogen I antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-PG I antibodies in PG I level test of animal Dog/Canine with atrophic gastritis, pernicious anemia, intestinal metaplasia, dysplasia, gastric polyps, and gastric cancer.
Tag	hFc
Products description	Anti-Canine PG I human monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-PG I antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Target/Biomarker information

Dog/Canine Prostaglandin I (PG I), or prostacyclin, emerges as a fundamental player in the intricate orchestra of canine cardiovascular physiology. This lipid compound, belonging to the prostaglandin family, boasts hormone-like functions and carries out its pivotal duties primarily within the endothelial cells that line the inner walls of blood vessels. Structurally, PG I showcases a 20-carbon chain with a cyclopentane ring structure, featuring a hydroxyl group. It is synthesized through the enzymatic action of prostacyclin synthase, an enzyme found predominantly within endothelial cells. This synthesis is a tightly regulated process, ensuring that PG I is available when needed to exert its critical functions. PG I's primary mission in canine physiology is to maintain vascular homeostasis. It achieves this by acting as a potent vasodilator, particularly in arterioles and capillaries. When released, PG I serves as a chemical messenger that signals the adjacent smooth muscle cells in the blood vessel walls to relax. This relaxation results in vasodilation, a widening of the blood vessel lumen. The consequence is a reduction in vascular resistance and an increase in blood vessel diameter, both of which facilitate optimal blood flow throughout the canine circulatory system. By promoting proper blood pressure and ensuring adequate perfusion of tissues, PG I plays a pivotal role in safeguarding cardiovascular health in dogs.

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