Canine PA antibody and antigen (recombinant protein)

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-CAN-PA-Ag01	Recombinant Canine PA protein	3090
GMP-CAN-PA-Ab01	Anti-Canine PA mouse monoclonal antibody (mAb)	1953
GMP-CAN-PA-Ab02	Anti-Canine PA mouse monoclonal antibody (mAb)	1953
GMP-CAN-PA-Ab03	Anti-Canine PA human monoclonal antibody (mAb)	1953
GMP-CAN-PA-Ab04	Anti-Canine PA human monoclonal antibody (mAb)	1953

Size： 1mg | 10mg | 100mg

Product Description

Cat No. of Products	GMP-CAN-PA-Ag01
Product Name	Recombinant Canine PA protein
Target/Biomarker	Canine Prealbumin (PA)
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Canine Prealbumin antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in PA level test of animal Dog/Canine with liver disease, inflammation, or tissue death.
Tag	His
Products description	Recombinant Canine PA protein was expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-CAN-PA-Ab01, GMP-CAN-PA-Ab02
Product Name	Anti-Canine PA mouse monoclonal antibody (mAb)
Target/Biomarker	Canine Prealbumin (PA)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Canine Prealbumin antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-PA antibodies in PA level test of animal Dog/Canine with liver disease, inflammation, or tissue death.
Tag	mFc
Products description	Anti-Canine PA mouse monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-PA antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-CAN-PA-Ab03, GMP-CAN-PA-Ab04
Product Name	Anti-Canine PA human monoclonal antibody (mAb)
Target/Biomarker	Canine Prealbumin (PA)
Expression platform	CHO
Isotypes	Human IgG1
Bioactivity validation	Recombinant Canine Prealbumin antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-PA antibodies in PA level test of animal Dog/Canine with liver disease, inflammation, or tissue death.
Tag	hFc
Products description	Anti-Canine PA human monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-PA antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Target/Biomarker information

Canine Prothrombin Activation Fragment 1+2 (cPAF1+2) represents a pivotal component in the intricate web of canine hemostasis. Structurally, it emerges as a fragment resulting from the activation of prothrombin (Factor II) into thrombin (Factor IIa), a process catalyzed by various coagulation factors and platelet interactions. This activation event is central to blood clot formation, serving as the gateway to the coagulation cascade. Prothrombin, an inert precursor protein, remains quiescent in the circulation until it encounters a vascular injury. Upon such an encounter, a series of enzymatic reactions ensue, leading to the cleavage of prothrombin into two fragments: thrombin and cPAF1+2. Thrombin, the multifaceted enzyme that emerges from this process, plays a pivotal role in the formation of a stable blood clot. It accomplishes this by catalyzing the conversion of soluble fibrinogen into insoluble fibrin strands, which, in turn, compose the structural scaffold of a clot. cPAF1+2, on the other hand, assumes a different role. It does not participate directly in clot formation but serves as an indispensable marker of ongoing thrombin generation. Its presence in the bloodstream reflects the dynamic equilibrium between prothrombin activation and thrombin regulation.

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