Canine NFL antibody and antigen (recombinant protein)

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-CAN-NFL-Ag01	Recombinant Canine NFL protein	3090
GMP-CAN-NFL-Ab01	Anti-Canine NFL mouse monoclonal antibody (mAb)	1953
GMP-CAN-NFL-Ab02	Anti-Canine NFL mouse monoclonal antibody (mAb)	1953
GMP-CAN-NFL-Ab03	Anti-Canine NFL human monoclonal antibody (mAb)	1953
GMP-CAN-NFL-Ab04	Anti-Canine NFL human monoclonal antibody (mAb)	1953

Size： 1mg | 10mg | 100mg

Product Description

Cat No. of Products	GMP-CAN-NFL-Ag01
Product Name	Recombinant Canine NFL protein
Target/Biomarker	Canine neurofilament light chain (NFL)
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Canine neurofilament light chain antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in NFL level test of animal Dog/Canine with Alzheimer Disease(AD).
Tag	His
Products description	Recombinant Canine NFL protein was expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-CAN-NFL-Ab01, GMP-CAN-NFL-Ab02
Product Name	Anti-Canine NFL mouse monoclonal antibody (mAb)
Target/Biomarker	Canine neurofilament light chain (NFL)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Canine neurofilament light chain antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-NFL antibodies in NFL level test of animal Dog/Canine with Alzheimer Disease(AD).
Tag	mFc
Products description	Anti-Canine NFL mouse monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-NFL antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-CAN-NFL-Ab03, GMP-CAN-NFL-Ab04
Product Name	Anti-Canine NFL human monoclonal antibody (mAb)
Target/Biomarker	Canine neurofilament light chain (NFL)
Expression platform	CHO
Isotypes	Human IgG1
Bioactivity validation	Recombinant Canine neurofilament light chain antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-NFL antibodies in NFL level test of animal Dog/Canine with Alzheimer Disease(AD).
Tag	hFc
Products description	Anti-Canine NFL human monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-NFL antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Target/Biomarker information

Canine Neurofilament Light Chain (NFL) represents a remarkable molecule in canine neurobiology, assuming a pivotal role in the maintenance of neuronal integrity and the assessment of neurological health in dogs. Structurally, NFL is a component of the neurofilament protein family, characterized by its filamentous nature and exclusive presence in the axons of neurons. Its primary function lies in providing structural support to neurons and facilitating efficient electrical signal transmission. NFL's significance amplifies in situations of neuronal injury or degeneration. When neurons are compromised due to various factors, including trauma, neurodegenerative disorders, or inflammation, NFL undergoes release from the damaged axons. These released NFL molecules enter the cerebrospinal fluid (CSF) and bloodstream, making it a quantifiable biomarker for neuronal damage. The dynamics of NFL release and measurement underscore its clinical relevance in the field of veterinary neurology. Elevated NFL levels signify ongoing neuronal damage or degeneration, often observed in conditions such as traumatic brain injury (TBI), spinal cord injury (SCI), canine degenerative myelopathy (CDM), and inflammatory disorders of the nervous system.

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