Canine MPO antibody and antigen (recombinant protein)

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-CAN-MPO-Ag01	Recombinant Canine MPO protein	3090
GMP-CAN-MPO-Ab01	Anti-Canine MPO mouse monoclonal antibody (mAb)	1953
GMP-CAN-MPO-Ab02	Anti-Canine MPO mouse monoclonal antibody (mAb)	1953
GMP-CAN-MPO-Ab03	Anti-Canine MPO human monoclonal antibody (mAb)	1953
GMP-CAN-MPO-Ab04	Anti-Canine MPO human monoclonal antibody (mAb)	1953

Size： 1mg | 10mg | 100mg

Product Description

Cat No. of Products	GMP-CAN-MPO-Ag01
Product Name	Recombinant Canine MPO protein
Target/Biomarker	Canine Myeloperoxidase (MPO)
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Canine Myeloperoxidase antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in MPO level test of animal Dog/Canine with vascular inflammation.
Tag	His
Products description	Recombinant Canine MPO protein was expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-CAN-MPO-Ab01, GMP-CAN-MPO-Ab02
Product Name	Anti-Canine MPO mouse monoclonal antibody (mAb)
Target/Biomarker	Canine Myeloperoxidase (MPO)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Canine Myeloperoxidase antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-MPO antibodies in MPO level test of animal Dog/Canine with vascular inflammation.
Tag	mFc
Products description	Anti-Canine MPO mouse monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-MPO antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-CAN-MPO-Ab03, GMP-CAN-MPO-Ab04
Product Name	Anti-Canine MPO human monoclonal antibody (mAb)
Target/Biomarker	Canine Myeloperoxidase (MPO)
Expression platform	CHO
Isotypes	Human IgG1
Bioactivity validation	Recombinant Canine Myeloperoxidase antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-MPO antibodies in MPO level test of animal Dog/Canine with vascular inflammation.
Tag	hFc
Products description	Anti-Canine MPO human monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-MPO antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Target/Biomarker information

Myeloperoxidase (MPO) is an enzyme of paramount importance within the canine immune system, specifically within neutrophils, the body's first line of defense against invading pathogens. MPO is housed primarily in the azurophilic granules of these specialized white blood cells. It serves as a critical component of the canine innate immune response. Structurally, MPO is a heme-containing enzyme, which means it contains iron atoms at its core. When neutrophils encounter microbial invaders, they unleash MPO into the surrounding environment as part of their antimicrobial weaponry. MPO's primary function is to catalyze the production of hypochlorous acid (HOCl) from hydrogen peroxide (H2O2) and chloride ions (Cl-). HOCl is a potent and reactive antimicrobial agent capable of swiftly neutralizing a broad spectrum of microorganisms, including bacteria, fungi, and viruses. MPO's mechanism of action involves the generation of reactive oxygen species (ROS), such as superoxide radicals and hydrogen peroxide, which are toxic to pathogens. Additionally, MPO promotes the conversion of chloride ions into hypochlorous acid, which exhibits potent antimicrobial properties, further enhancing the neutrophils' ability to eliminate invaders.

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