Canine Ins antibody and antigen (recombinant protein)

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-CAN-Ins-Ag01	Recombinant Canine Ins protein	3090
GMP-CAN-Ins-Ab01	Anti-Canine Ins mouse monoclonal antibody (mAb)	1953
GMP-CAN-Ins-Ab02	Anti-Canine Ins mouse monoclonal antibody (mAb)	1953
GMP-CAN-Ins-Ab03	Anti-Canine Ins human monoclonal antibody (mAb)	1953
GMP-CAN-Ins-Ab04	Anti-Canine Ins human monoclonal antibody (mAb)	1953

Size： 1mg | 10mg | 100mg

Product Description

Cat No. of Products	GMP-CAN-Ins-Ag01
Product Name	Recombinant Canine Ins protein
Target/Biomarker	Canine Insulin (Ins)
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Canine Insulin antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in Ins level test of animal Dog/Canine with Diabetes mellitus.
Tag	His
Products description	Recombinant Canine Ins protein was expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-CAN-Ins-Ab01, GMP-CAN-Ins-Ab02
Product Name	Anti-Canine Ins mouse monoclonal antibody (mAb)
Target/Biomarker	Canine Insulin (Ins)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Canine Insulin antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Ins antibodies in Ins level test of animal Dog/Canine with Diabetes mellitus.
Tag	mFc
Products description	Anti-Canine Ins mouse monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Ins antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-CAN-Ins-Ab03, GMP-CAN-Ins-Ab04
Product Name	Anti-Canine Ins human monoclonal antibody (mAb)
Target/Biomarker	Canine Insulin (Ins)
Expression platform	CHO
Isotypes	Human IgG1
Bioactivity validation	Recombinant Canine Insulin antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Ins antibodies in Ins level test of animal Dog/Canine with Diabetes mellitus.
Tag	hFc
Products description	Anti-Canine Ins human monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Ins antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Target/Biomarker information

Canine Insulin, when associated with Human Insulin, embodies the essence of a finely tuned molecular machinery that regulates glucose metabolism in dogs. It is produced by the beta cells of the canine pancreas and plays a pivotal role in the intricate web of metabolic processes that maintain blood sugar equilibrium. While there are subtle structural differences between Canine Insulin and its human counterpart, they share fundamental similarities in their mechanisms of action. Both insulins serve as molecular keys, unlocking the doors of cells to allow glucose uptake from the bloodstream. This glucose uptake is essential for energy production, fueling the various cellular processes that sustain life. In the context of diabetic dogs, Canine Insulin often refers to Human Insulin, which is used therapeutically to restore glycemic control. Diabetes mellitus in dogs can manifest as Type 1 or Type 2 diabetes. In Type 1 diabetes, the pancreas fails to produce sufficient insulin, while in Type 2 diabetes, the cells exhibit reduced responsiveness to insulin. In either case, elevated blood glucose levels are the hallmark. The administration of Human Insulin in diabetic dogs addresses this underlying deficiency or resistance, enabling glucose uptake by cells and thus lowering blood sugar levels. While Human Insulin isn't identical to Canine Insulin, its efficacy in managing canine diabetes is well-established, making it a mainstay in veterinary medicine.

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