Canine IgG antibody and antigen (recombinant protein)

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-CAN-IgG-Ag01	Recombinant Canine IgG protein	3090
GMP-CAN-IgG-Ab01	Anti-Canine IgG mouse monoclonal antibody (mAb)	1953
GMP-CAN-IgG-Ab02	Anti-Canine IgG mouse monoclonal antibody (mAb)	1953
GMP-CAN-IgG-Ab03	Anti-Canine IgG human monoclonal antibody (mAb)	1953
GMP-CAN-IgG-Ab04	Anti-Canine IgG human monoclonal antibody (mAb)	1953

Size： 1mg | 10mg | 100mg

Product Description

Cat No. of Products	GMP-CAN-IgG-Ag01
Product Name	Recombinant Canine IgG protein
Target/Biomarker	Canine IgG (Canine IgG)
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Canine IgG antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in Canine IgG level test of animal Dog/Canine with N/A.
Tag	His
Products description	Recombinant Canine IgG protein was expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-CAN-IgG-Ab01, GMP-CAN-IgG-Ab02
Product Name	Anti-Canine IgG mouse monoclonal antibody (mAb)
Target/Biomarker	Canine IgG (Canine IgG)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Canine IgG antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Canine IgG antibodies in Canine IgG level test of animal Dog/Canine with N/A.
Tag	mFc
Products description	Anti-Canine IgG mouse monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Canine IgG antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-CAN-IgG-Ab03, GMP-CAN-IgG-Ab04
Product Name	Anti-Canine IgG human monoclonal antibody (mAb)
Target/Biomarker	Canine IgG (Canine IgG)
Expression platform	CHO
Isotypes	Human IgG1
Bioactivity validation	Recombinant Canine IgG antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Canine IgG antibodies in Canine IgG level test of animal Dog/Canine with N/A.
Tag	hFc
Products description	Anti-Canine IgG human monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Canine IgG antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Target/Biomarker information

Canine Immunoglobulin G (IgG) stands as a cornerstone of the intricate canine immune system. Structurally, IgG is a glycoprotein with a Y-shaped configuration, composed of two identical heavy chains and two identical light chains, linked together by disulfide bonds. Each IgG molecule boasts remarkable specificity, with its antigen-binding regions designed to recognize and bind to a vast array of pathogens. The production of IgG antibodies in dogs is a meticulously orchestrated process. B cells, a type of white blood cell, are activated when they encounter antigens—foreign substances or pathogens. Upon activation, B cells undergo a transformation, differentiating into plasma cells, which are specialized factories for IgG production. These plasma cells churn out copious amounts of IgG antibodies, which are then released into the bloodstream. Canine IgG antibodies serve as vigilant sentinels, patrolling the circulatory system and tissues, ever ready to confront invading microorganisms. When they encounter an antigen they've been designed to recognize, a cascade of events is triggered. IgG binds to the antigen with high specificity, forming an antigen-antibody complex. This interaction can have several outcomes: neutralization of the pathogen, activation of other immune cells to eliminate the threat, or marking the pathogen for destruction. One of the remarkable aspects of canine IgG is its role in providing long-lasting immunity. After an initial encounter with an antigen, memory B cells are formed. These cells "remember" the specific pathogen and can rapidly produce IgG antibodies if the same antigen enters the body again. This mechanism is the foundation of adaptive immunity and enables dogs to mount a quicker and more effective response upon reexposure to the pathogen.

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