Canine IL-6 antibody and antigen (recombinant protein)

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-CAN-IL-6-Ag01	Recombinant Canine IL-6 protein	3090
GMP-CAN-IL-6-Ab01	Anti-Canine IL-6 mouse monoclonal antibody (mAb)	1953
GMP-CAN-IL-6-Ab02	Anti-Canine IL-6 mouse monoclonal antibody (mAb)	1953
GMP-CAN-IL-6-Ab03	Anti-Canine IL-6 human monoclonal antibody (mAb)	1953
GMP-CAN-IL-6-Ab04	Anti-Canine IL-6 human monoclonal antibody (mAb)	1953

Size： 1mg | 10mg | 100mg

Product Description

Cat No. of Products	GMP-CAN-IL-6-Ag01
Product Name	Recombinant Canine IL-6 protein
Target/Biomarker	Canine Interleukin 6 (IL-6)
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Canine Interleukin 6 antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in IL-6 level test of animal Dog/Canine with systemic juvenile idiopathic arthritis, systemic lupus erythematosus, ankylosing spondylitis, psoriasis and Crohn's disease..
Tag	His
Products description	Recombinant Canine IL-6 protein was expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-CAN-IL-6-Ab01, GMP-CAN-IL-6-Ab02
Product Name	Anti-Canine IL-6 mouse monoclonal antibody (mAb)
Target/Biomarker	Canine Interleukin 6 (IL-6)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Canine Interleukin 6 antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-IL-6 antibodies in IL-6 level test of animal Dog/Canine with systemic juvenile idiopathic arthritis, systemic lupus erythematosus, ankylosing spondylitis, psoriasis and Crohn's disease..
Tag	mFc
Products description	Anti-Canine IL-6 mouse monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-IL-6 antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-CAN-IL-6-Ab03, GMP-CAN-IL-6-Ab04
Product Name	Anti-Canine IL-6 human monoclonal antibody (mAb)
Target/Biomarker	Canine Interleukin 6 (IL-6)
Expression platform	CHO
Isotypes	Human IgG1
Bioactivity validation	Recombinant Canine Interleukin 6 antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-IL-6 antibodies in IL-6 level test of animal Dog/Canine with systemic juvenile idiopathic arthritis, systemic lupus erythematosus, ankylosing spondylitis, psoriasis and Crohn's disease..
Tag	hFc
Products description	Anti-Canine IL-6 human monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-IL-6 antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

Click to get more Data / Case study about the product.

Target/Biomarker information

Interleukin-6 (IL-6) stands as a multifaceted cytokine in the realm of canine health, playing a pivotal role in immune regulation and inflammation management. This biomarker is produced by a diverse array of cells, including white blood cells (leukocytes), macrophages, and fibroblasts, in response to various physiological stimuli. In dogs, IL-6's functions are diverse and context-dependent. It serves as both a pro-inflammatory and anti-inflammatory cytokine, responding dynamically to the body's needs. During acute infections or tissue injuries, IL-6 is released to trigger an immediate immune response, recruiting immune cells to the site of infection or injury and enhancing their activity. Moreover, IL-6 supports the liver in producing acute-phase proteins, which are essential for the body's defense mechanisms. However, it's essential to note that prolonged or excessive IL-6 production can lead to chronic inflammation, which is implicated in various diseases, including autoimmune disorders and certain cancers. Dysregulation of IL-6 is associated with health issues, making its measurement in dogs a valuable diagnostic tool. IL-6 levels can be assessed through blood tests, allowing veterinarians to gauge a dog's immune status and inflammatory state. Elevated levels of IL-6 often indicate the presence of inflammation or infection. This makes IL-6 a sensitive biomarker for diagnosing and monitoring a spectrum of canine diseases, from simple infections to complex autoimmune conditions.

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