Canine HER2 antibody and antigen (recombinant protein)

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-CAN-HER2-Ag01	Recombinant Canine HER2 protein	3090
GMP-CAN-HER2-Ab01	Anti-Canine HER2 mouse monoclonal antibody (mAb)	1953
GMP-CAN-HER2-Ab02	Anti-Canine HER2 mouse monoclonal antibody (mAb)	1953
GMP-CAN-HER2-Ab03	Anti-Canine HER2 human monoclonal antibody (mAb)	1953
GMP-CAN-HER2-Ab04	Anti-Canine HER2 human monoclonal antibody (mAb)	1953

Size： 1mg | 10mg | 100mg

Product Description

Cat No. of Products	GMP-CAN-HER2-Ag01
Product Name	Recombinant Canine HER2 protein
Target/Biomarker	Canine Epidermal Growth Factor Receptor 2 (HER2)
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Canine Epidermal Growth Factor Receptor 2 antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in HER2 level test of animal Dog/Canine with breast cancer.
Tag	His
Products description	Recombinant Canine HER2 protein was expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-CAN-HER2-Ab01, GMP-CAN-HER2-Ab02
Product Name	Anti-Canine HER2 mouse monoclonal antibody (mAb)
Target/Biomarker	Canine Epidermal Growth Factor Receptor 2 (HER2)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Canine Epidermal Growth Factor Receptor 2 antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-HER2 antibodies in HER2 level test of animal Dog/Canine with breast cancer.
Tag	mFc
Products description	Anti-Canine HER2 mouse monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-HER2 antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-CAN-HER2-Ab03, GMP-CAN-HER2-Ab04
Product Name	Anti-Canine HER2 human monoclonal antibody (mAb)
Target/Biomarker	Canine Epidermal Growth Factor Receptor 2 (HER2)
Expression platform	CHO
Isotypes	Human IgG1
Bioactivity validation	Recombinant Canine Epidermal Growth Factor Receptor 2 antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-HER2 antibodies in HER2 level test of animal Dog/Canine with breast cancer.
Tag	hFc
Products description	Anti-Canine HER2 human monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-HER2 antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Target/Biomarker information

HER2, also known as Human Epidermal Growth Factor Receptor 2, is a biomarker of significant importance within the realm of dogs (canines). This transmembrane protein receptor belongs to the epidermal growth factor receptor (EGFR) family and is primarily found on the surface of certain canine cells. Its primary role is to regulate cell growth and proliferation by participating in intracellular signaling pathways that promote cell division. In normal canine cells, HER2 plays a crucial role in maintaining a balanced and controlled rate of cell growth. It does so by facilitating the transmission of growth-promoting signals. However, when genetic mutations or alterations in HER2 expression occur, this finely tuned system can go awry, leading to uncontrolled cell growth—a hallmark feature of cancer. The significance of HER2 abnormalities becomes particularly pronounced in the context of canine mammary gland tumors, where HER2 overexpression is associated with aggressive tumor behavior.

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