Canine GFAP antibody and antigen (recombinant protein)

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-CAN-GFAP-Ag01	Recombinant Canine GFAP protein	3090
GMP-CAN-GFAP-Ab01	Anti-Canine GFAP mouse monoclonal antibody (mAb)	1953
GMP-CAN-GFAP-Ab02	Anti-Canine GFAP mouse monoclonal antibody (mAb)	1953
GMP-CAN-GFAP-Ab03	Anti-Canine GFAP human monoclonal antibody (mAb)	1953
GMP-CAN-GFAP-Ab04	Anti-Canine GFAP human monoclonal antibody (mAb)	1953

Size： 1mg | 10mg | 100mg

Product Description

Cat No. of Products	GMP-CAN-GFAP-Ag01
Product Name	Recombinant Canine GFAP protein
Target/Biomarker	Canine Glial fibrillary acid protein (GFAP)
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Canine Glial fibrillary acid protein antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in GFAP level test of animal Dog/Canine with Alzheimer Disease(AD).
Tag	His
Products description	Recombinant Canine GFAP protein was expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-CAN-GFAP-Ab01, GMP-CAN-GFAP-Ab02
Product Name	Anti-Canine GFAP mouse monoclonal antibody (mAb)
Target/Biomarker	Canine Glial fibrillary acid protein (GFAP)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Canine Glial fibrillary acid protein antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-GFAP antibodies in GFAP level test of animal Dog/Canine with Alzheimer Disease(AD).
Tag	mFc
Products description	Anti-Canine GFAP mouse monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-GFAP antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-CAN-GFAP-Ab03, GMP-CAN-GFAP-Ab04
Product Name	Anti-Canine GFAP human monoclonal antibody (mAb)
Target/Biomarker	Canine Glial fibrillary acid protein (GFAP)
Expression platform	CHO
Isotypes	Human IgG1
Bioactivity validation	Recombinant Canine Glial fibrillary acid protein antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-GFAP antibodies in GFAP level test of animal Dog/Canine with Alzheimer Disease(AD).
Tag	hFc
Products description	Anti-Canine GFAP human monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-GFAP antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Target/Biomarker information

Canine GFAP, or Glial Fibrillary Acidic Protein, stands as a sentinel within the intricate realm of canine neurobiology. This protein, primarily residing in astrocytes within the central nervous system (CNS) of dogs, plays multifaceted roles in maintaining the structural and functional integrity of the nervous system. Structurally, Canine GFAP is a member of the intermediate filament protein family, sharing genetic and functional homology with its counterparts in diverse species, including humans. Astrocytes, the primary cellular reservoir of GFAP, rely on this protein for structural support and cytoskeletal integrity. Canine GFAP filaments form a complex network within astrocytes, contributing to their resilience and capacity to respond to various challenges. Functionally, Canine GFAP is instrumental in astrocyte-mediated processes that support neuronal health. Astrocytes nourish neurons, regulate synaptic transmission, modulate neurotransmitter levels, and maintain the blood-brain barrier. Canine GFAP actively participates in these functions, ensuring the optimal functioning of the CNS. However, the significance of Canine GFAP extends beyond its structural and homeostatic roles. In response to CNS injury, neuroinflammation, or neurodegenerative conditions, astrocytes undergo a transformative process known as astrogliosis. During astrogliosis, astrocytes become activated, leading to increased expression of GFAP. This upregulation serves as a protective and reparative response, as astrocytes encapsulate injured areas, isolate toxic substances, and support neuronal recovery.

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