Canine G100 antibody and antigen (recombinant protein)

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-CAN-G100-Ag01	Recombinant Canine G100 protein	3090
GMP-CAN-G100-Ab01	Anti-Canine G100 mouse monoclonal antibody (mAb)	1953
GMP-CAN-G100-Ab02	Anti-Canine G100 mouse monoclonal antibody (mAb)	1953
GMP-CAN-G100-Ab03	Anti-Canine G100 human monoclonal antibody (mAb)	1953
GMP-CAN-G100-Ab04	Anti-Canine G100 human monoclonal antibody (mAb)	1953

Size： 1mg | 10mg | 100mg

Product Description

Cat No. of Products	GMP-CAN-G100-Ag01
Product Name	Recombinant Canine G100 protein
Target/Biomarker	Canine Gastrin (G100)
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Canine Gastrin antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in G100 level test of animal Dog/Canine with gastrinoma.
Tag	His
Products description	Recombinant Canine G100 protein was expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-CAN-G100-Ab01, GMP-CAN-G100-Ab02
Product Name	Anti-Canine G100 mouse monoclonal antibody (mAb)
Target/Biomarker	Canine Gastrin (G100)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Canine Gastrin antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-G100 antibodies in G100 level test of animal Dog/Canine with gastrinoma.
Tag	mFc
Products description	Anti-Canine G100 mouse monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-G100 antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-CAN-G100-Ab03, GMP-CAN-G100-Ab04
Product Name	Anti-Canine G100 human monoclonal antibody (mAb)
Target/Biomarker	Canine Gastrin (G100)
Expression platform	CHO
Isotypes	Human IgG1
Bioactivity validation	Recombinant Canine Gastrin antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-G100 antibodies in G100 level test of animal Dog/Canine with gastrinoma.
Tag	hFc
Products description	Anti-Canine G100 human monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-G100 antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Target/Biomarker information

Dog/Canine Gastrin stands as a fascinating hormone, intricately woven into the fabric of canine digestion. This peptide hormone is produced primarily by G cells, specialized enteroendocrine cells that reside within the mucosa of the stomach and duodenum in dogs. The journey of Gastrin commences with the ingestion of food. When a dog consumes a meal, particularly one rich in proteins, it triggers the release of Gastrin. Gastrin, in turn, exerts its influence on parietal cells located in the gastric mucosa. These parietal cells are responsible for secreting hydrochloric acid (HCl), a potent digestive enzyme. Gastrin's binding to specific receptors on parietal cells prompts them to increase their production of HCl. The surge in gastric acid serves a critical purpose in digestion. It creates an optimal acidic environment within the stomach, crucial for the activation of pepsin, another vital enzyme that participates in protein digestion. Pepsinogen, an inactive form of pepsin, is activated in the acidic milieu of the stomach and plays a pivotal role in breaking down complex proteins into more digestible fragments. The regulation of Gastrin secretion is a sophisticated process that hinges on feedback mechanisms. When the pH level in the stomach reaches an appropriately acidic state, it signals the inhibition of Gastrin release. This negative feedback loop prevents excessive acid production, ensuring that the digestive process remains finely tuned to the dietary content and digestive needs of the dog. Furthermore, Gastrin exhibits variations in secretion patterns in response to different dietary components. For instance, the presence of amino acids, particularly phenylalanine and tryptophan, can stimulate Gastrin release. This sensitivity to dietary cues underscores Gastrin's role as a key mediator of digestion, finely attuned to the nutritional composition of the dog's diet.

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