Canine FIB antibody and antigen (recombinant protein)

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-CAN-FIB-Ag01	Recombinant Canine FIB protein	3090
GMP-CAN-FIB-Ab01	Anti-Canine FIB mouse monoclonal antibody (mAb)	1953
GMP-CAN-FIB-Ab02	Anti-Canine FIB mouse monoclonal antibody (mAb)	1953
GMP-CAN-FIB-Ab03	Anti-Canine FIB human monoclonal antibody (mAb)	1953
GMP-CAN-FIB-Ab04	Anti-Canine FIB human monoclonal antibody (mAb)	1953

Size： 1mg | 10mg | 100mg

Product Description

Cat No. of Products	GMP-CAN-FIB-Ag01
Product Name	Recombinant Canine FIB protein
Target/Biomarker	Canine Fibrinogen (FIB)
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Canine Fibrinogen antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in FIB level test of animal Dog/Canine with congenital afibrinogenemia, congenital hypofibrinogenemia, fibrinogen storage disease, congenital dysfibrinogenemia, hereditary fibrinogen Aα-Chain amyloidosis, acquired dysfibrinogenemia, congenital hypodysfibrinogenemia, and cryofibrinogenemia.
Tag	His
Products description	Recombinant Canine FIB protein was expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-CAN-FIB-Ab01, GMP-CAN-FIB-Ab02
Product Name	Anti-Canine FIB mouse monoclonal antibody (mAb)
Target/Biomarker	Canine Fibrinogen (FIB)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Canine Fibrinogen antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-FIB antibodies in FIB level test of animal Dog/Canine with congenital afibrinogenemia, congenital hypofibrinogenemia, fibrinogen storage disease, congenital dysfibrinogenemia, hereditary fibrinogen Aα-Chain amyloidosis, acquired dysfibrinogenemia, congenital hypodysfibrinogenemia, and cryofibrinogenemia.
Tag	mFc
Products description	Anti-Canine FIB mouse monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-FIB antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-CAN-FIB-Ab03, GMP-CAN-FIB-Ab04
Product Name	Anti-Canine FIB human monoclonal antibody (mAb)
Target/Biomarker	Canine Fibrinogen (FIB)
Expression platform	CHO
Isotypes	Human IgG1
Bioactivity validation	Recombinant Canine Fibrinogen antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-FIB antibodies in FIB level test of animal Dog/Canine with congenital afibrinogenemia, congenital hypofibrinogenemia, fibrinogen storage disease, congenital dysfibrinogenemia, hereditary fibrinogen Aα-Chain amyloidosis, acquired dysfibrinogenemia, congenital hypodysfibrinogenemia, and cryofibrinogenemia.
Tag	hFc
Products description	Anti-Canine FIB human monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-FIB antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Target/Biomarker information

Canine Fibrinogen, an intricate player in the dog's hemostatic orchestra, merits a closer examination. Structurally, it is a glycoprotein of considerable complexity, comprising three polypeptide chains: alpha, beta, and gamma. These chains intertwine to form a large, hexameric molecule with a molecular mass of approximately 340 kDa. Synthesized predominantly in the liver, canine fibrinogen is released into the bloodstream, where it awaits its crucial role in maintaining hemostasis. The cornerstone of canine fibrinogen's function lies in its conversion to fibrin, the scaffolding upon which blood clots are constructed. This conversion is orchestrated by the enzyme thrombin, which cleaves fibrinogen's alpha and beta chains, unleashing fibrin's polymerization potential. Fibrin threads emerge from this process, interweaving into a meshwork that entraps blood cells, forming the foundation of a blood clot. Canine fibrinogen's dynamic nature renders it a versatile biomarker. Its concentrations can fluctuate in response to various physiological and pathological stimuli. In instances of inflammation, infection, or tissue injury, fibrinogen synthesis in the liver escalates as part of the acute-phase response. This elevation serves a protective purpose, fortifying the body's ability to staunch bleeding at the site of injury.

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