Canine CYFRA21-1 antibody and antigen (recombinant protein)

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-CAN-CYFRA21-1-Ag01	Recombinant Canine CYFRA21-1 protein	3090
GMP-CAN-CYFRA21-1-Ab01	Anti-Canine CYFRA21-1 mouse monoclonal antibody (mAb)	1953
GMP-CAN-CYFRA21-1-Ab02	Anti-Canine CYFRA21-1 mouse monoclonal antibody (mAb)	1953
GMP-CAN-CYFRA21-1-Ab03	Anti-Canine CYFRA21-1 human monoclonal antibody (mAb)	1953
GMP-CAN-CYFRA21-1-Ab04	Anti-Canine CYFRA21-1 human monoclonal antibody (mAb)	1953

Size： 1mg | 10mg | 100mg

Product Description

Cat No. of Products	GMP-CAN-CYFRA21-1-Ag01
Product Name	Recombinant Canine CYFRA21-1 protein
Target/Biomarker	Canine soluble fragment of cytokeratin-19 (CYFRA21-1)
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Canine soluble fragment of cytokeratin-19 antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in CYFRA21-1 level test of animal Dog/Canine with bronchopulmonary dysplasia.
Tag	His
Products description	Recombinant Canine CYFRA21-1 protein was expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-CAN-CYFRA21-1-Ab01, GMP-CAN-CYFRA21-1-Ab02
Product Name	Anti-Canine CYFRA21-1 mouse monoclonal antibody (mAb)
Target/Biomarker	Canine soluble fragment of cytokeratin-19 (CYFRA21-1)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Canine soluble fragment of cytokeratin-19 antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-CYFRA21-1 antibodies in CYFRA21-1 level test of animal Dog/Canine with bronchopulmonary dysplasia.
Tag	mFc
Products description	Anti-Canine CYFRA21-1 mouse monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-CYFRA21-1 antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-CAN-CYFRA21-1-Ab03, GMP-CAN-CYFRA21-1-Ab04
Product Name	Anti-Canine CYFRA21-1 human monoclonal antibody (mAb)
Target/Biomarker	Canine soluble fragment of cytokeratin-19 (CYFRA21-1)
Expression platform	CHO
Isotypes	Human IgG1
Bioactivity validation	Recombinant Canine soluble fragment of cytokeratin-19 antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-CYFRA21-1 antibodies in CYFRA21-1 level test of animal Dog/Canine with bronchopulmonary dysplasia.
Tag	hFc
Products description	Anti-Canine CYFRA21-1 human monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-CYFRA21-1 antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Target/Biomarker information

CYFRA21-1, also known as Cytokeratin 19 Fragment 21-1, is a noteworthy biomarker within the context of dogs (canines). It originates from cytokeratin 19, a protein that plays a pivotal role in maintaining the structural integrity of epithelial cells. Epithelial cells are widespread in various tissues throughout the canine body, including the lungs and skin. When these cells undergo changes due to injury, malignancy, or other pathological processes, CYFRA21-1 fragments can be released into the bloodstream, making it a valuable indicator of epithelial cell health. At the molecular level, CYFRA21-1 consists of specific fragments of cytokeratin 19, notably the 21-1 fragment. These soluble protein fragments can be detected through blood tests. In healthy dogs, CYFRA21-1 levels are typically low. However, when there is damage or malignancy in epithelial tissues, such as the lungs, the levels of CYFRA21-1 can significantly increase. This phenomenon makes CYFRA21-1 a crucial biomarker for assessing the health of the respiratory and epithelial systems in canines.

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