Canine CBL antibody and antigen (recombinant protein)

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-CAN-CBL-Ag01	Recombinant Canine CBL protein	3090
GMP-CAN-CBL-Ab01	Anti-Canine CBL mouse monoclonal antibody (mAb)	1953
GMP-CAN-CBL-Ab02	Anti-Canine CBL mouse monoclonal antibody (mAb)	1953
GMP-CAN-CBL-Ab03	Anti-Canine CBL human monoclonal antibody (mAb)	1953
GMP-CAN-CBL-Ab04	Anti-Canine CBL human monoclonal antibody (mAb)	1953

Size： 1mg | 10mg | 100mg

Product Description

Cat No. of Products	GMP-CAN-CBL-Ag01
Product Name	Recombinant Canine CBL protein
Target/Biomarker	Canine cystathionine-β-synthase enzyme ()
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Canine cystathionine-β-synthase enzyme antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in level test of animal Dog/Canine with ectopia lentis, learning difficulties and skeletal abnormalities.
Tag	His
Products description	Recombinant Canine CBL protein was expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-CAN-CBL-Ab01, GMP-CAN-CBL-Ab02
Product Name	Anti-Canine CBL mouse monoclonal antibody (mAb)
Target/Biomarker	Canine cystathionine-β-synthase enzyme ()
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Canine cystathionine-β-synthase enzyme antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti- antibodies in level test of animal Dog/Canine with ectopia lentis, learning difficulties and skeletal abnormalities.
Tag	mFc
Products description	Anti-Canine CBL mouse monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti- antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-CAN-CBL-Ab03, GMP-CAN-CBL-Ab04
Product Name	Anti-Canine CBL human monoclonal antibody (mAb)
Target/Biomarker	Canine cystathionine-β-synthase enzyme ()
Expression platform	CHO
Isotypes	Human IgG1
Bioactivity validation	Recombinant Canine cystathionine-β-synthase enzyme antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti- antibodies in level test of animal Dog/Canine with ectopia lentis, learning difficulties and skeletal abnormalities.
Tag	hFc
Products description	Anti-Canine CBL human monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti- antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Target/Biomarker information

Cobalamin, or Vitamin B12, is a veritable biochemical marvel within the canine (dog) population. This water-soluble vitamin, represented by the biomarker CBL, serves as a linchpin in countless metabolic pathways critical to canine health and vitality. At its heart, Vitamin B12 boasts a complex molecular structure, characterized by a central cobalt atom. This cobalt atom is the epicenter of Vitamin B12's biological activity, essential for its role as a cofactor in enzymatic reactions vital to a dog's well-being. One of Vitamin B12's pivotal roles is in the conversion of methylmalonyl-CoA to succinyl-CoA, a process catalyzed by the enzyme methylmalonyl-CoA mutase. This reaction has far-reaching implications, as it contributes to the metabolism of fatty acids and amino acids. Additionally, Vitamin B12 participates in the conversion of homocysteine to methionine, a reaction catalyzed by methionine synthase. Methionine is a fundamental amino acid, and its synthesis is indispensable for protein production and overall cellular function. Beyond its involvement in amino acid and fatty acid metabolism, Vitamin B12 holds a critical place in DNA synthesis. Dogs rely on Vitamin B12 for the production of thymidine, one of the four nucleotide building blocks of DNA. This role is foundational for growth, tissue repair, and overall canine development. Vitamin B12's significance extends to the production of myelin, the insulating sheath that envelops nerve fibers. Myelin ensures efficient transmission of nerve impulses, underpinning neurological function. Furthermore, Vitamin B12 plays a key role in heme synthesis, a vital component of hemoglobin within red blood cells. Hemoglobin's function in oxygen transport makes it central to canine vitality.

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