Canine ApoE antibody and antigen (recombinant protein)

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-CAN-ApoE-Ag01	Recombinant Canine ApoE protein	3090
GMP-CAN-ApoE-Ab01	Anti-Canine ApoE mouse monoclonal antibody (mAb)	1953
GMP-CAN-ApoE-Ab02	Anti-Canine ApoE mouse monoclonal antibody (mAb)	1953
GMP-CAN-ApoE-Ab03	Anti-Canine ApoE human monoclonal antibody (mAb)	1953
GMP-CAN-ApoE-Ab04	Anti-Canine ApoE human monoclonal antibody (mAb)	1953

Size： 1mg | 10mg | 100mg

Product Description

Cat No. of Products	GMP-CAN-ApoE-Ag01
Product Name	Recombinant Canine ApoE protein
Target/Biomarker	Canine Apolipoprotein E (ARV)
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Canine Apolipoprotein E antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in ARV level test of animal Dog/Canine with Cardiovascular Disease.
Tag	His
Products description	Recombinant Canine ApoE protein was expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-CAN-ApoE-Ab01, GMP-CAN-ApoE-Ab02
Product Name	Anti-Canine ApoE mouse monoclonal antibody (mAb)
Target/Biomarker	Canine Apolipoprotein E (ARV)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Canine Apolipoprotein E antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-ARV antibodies in ARV level test of animal Dog/Canine with Cardiovascular Disease.
Tag	mFc
Products description	Anti-Canine ApoE mouse monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-ARV antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-CAN-ApoE-Ab03, GMP-CAN-ApoE-Ab04
Product Name	Anti-Canine ApoE human monoclonal antibody (mAb)
Target/Biomarker	Canine Apolipoprotein E (ARV)
Expression platform	CHO
Isotypes	Human IgG1
Bioactivity validation	Recombinant Canine Apolipoprotein E antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-ARV antibodies in ARV level test of animal Dog/Canine with Cardiovascular Disease.
Tag	hFc
Products description	Anti-Canine ApoE human monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-ARV antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Target/Biomarker information

Canine Apolipoprotein E, more commonly referred to as Canine ApoE, is a multifaceted protein that holds a central position in the intricate landscape of canine physiology. Synthesized predominantly in the liver and brain of domestic dogs (Canis lupus familiaris), this glycoprotein possesses a distinctive structure characterized by carbohydrates attached to its polypeptide chain. As a distinguished member of the apolipoprotein family, Canine ApoE plays a pivotal role in regulating lipid metabolism, with a particular emphasis on cholesterol management within the canine body. The significance of Canine ApoE becomes most apparent in its association with high-density lipoproteins (HDL), widely recognized as "good cholesterol." HDL particles, responsible for transporting cholesterol and lipids in the bloodstream, rely significantly on Canine ApoE for their structural integrity and functionality. This biomarker is an indispensable component of HDLs, contributing not only to their structural integrity but also to their dynamic role in the reverse cholesterol transport pathway. The orchestration of cholesterol transport begins when Canine ApoE binds to lipids, effectively transforming nascent HDL particles into active carriers of excess cholesterol. These HDLs venture into peripheral tissues, retrieving surplus cholesterol and lipids, and then embark on a journey back to the liver. In the liver, cholesterol undergoes metabolism and eventual excretion, thus ensuring the maintenance of healthy cholesterol levels within the canine body.

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