Canine AD7c-NTP antibody and antigen (recombinant protein)

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-CAN-AD7c-NTP-Ag01	Recombinant Canine AD7c-NTP protein	3090
GMP-CAN-AD7c-NTP-Ab01	Anti-Canine AD7c-NTP mouse monoclonal antibody (mAb)	1953
GMP-CAN-AD7c-NTP-Ab02	Anti-Canine AD7c-NTP mouse monoclonal antibody (mAb)	1953
GMP-CAN-AD7c-NTP-Ab03	Anti-Canine AD7c-NTP human monoclonal antibody (mAb)	1953
GMP-CAN-AD7c-NTP-Ab04	Anti-Canine AD7c-NTP human monoclonal antibody (mAb)	1953

Size： 1mg | 10mg | 100mg

Product Description

Cat No. of Products	GMP-CAN-AD7c-NTP-Ag01
Product Name	Recombinant Canine AD7c-NTP protein
Target/Biomarker	Canine AD-associated neuaronal thread protein (AD7c-NTP)
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Canine AD-associated neuaronal thread protein antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in AD7c-NTP level test of animal Dog/Canine with Alzheimer Disease(AD).
Tag	His
Products description	Recombinant Canine AD7c-NTP protein was expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-CAN-AD7c-NTP-Ab01, GMP-CAN-AD7c-NTP-Ab02
Product Name	Anti-Canine AD7c-NTP mouse monoclonal antibody (mAb)
Target/Biomarker	Canine AD-associated neuaronal thread protein (AD7c-NTP)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Canine AD-associated neuaronal thread protein antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-AD7c-NTP antibodies in AD7c-NTP level test of animal Dog/Canine with Alzheimer Disease(AD).
Tag	mFc
Products description	Anti-Canine AD7c-NTP mouse monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-AD7c-NTP antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-CAN-AD7c-NTP-Ab03, GMP-CAN-AD7c-NTP-Ab04
Product Name	Anti-Canine AD7c-NTP human monoclonal antibody (mAb)
Target/Biomarker	Canine AD-associated neuaronal thread protein (AD7c-NTP)
Expression platform	CHO
Isotypes	Human IgG1
Bioactivity validation	Recombinant Canine AD-associated neuaronal thread protein antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-AD7c-NTP antibodies in AD7c-NTP level test of animal Dog/Canine with Alzheimer Disease(AD).
Tag	hFc
Products description	Anti-Canine AD7c-NTP human monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-AD7c-NTP antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Target/Biomarker information

Canine AD-associated Neuronal Thread Protein (AD7c-NTP) represents a pivotal protagonist in the intricate narrative of canine neurodegeneration. Structurally reminiscent of its human counterpart, AD7c-NTP is a neuronal protein that finds itself intimately woven into the fabric of neurofibrillary tangle formation, a central pathological feature shared with Alzheimer's disease (AD). The journey of AD7c-NTP begins within the canine brain, where it partakes in the complex choreography of neurofibrillary tangle assembly. These tangles, characterized by their twisted filaments primarily composed of AD7c-NTP, are emblematic of cognitive dysfunction and memory impairment in dogs. This phenomenon parallels the neurofibrillary tangles seen in humans with AD, underscoring the evolutionary conservation of neurodegenerative processes. At a molecular level, the aggregation of AD7c-NTP and its entanglement with other associated proteins give rise to the neurofibrillary tangles that disrupt the normal architecture and function of neurons. This disruption leads to neuronal death and synapse loss, ultimately manifesting as the cognitive deficits observed in dogs afflicted with canine cognitive dysfunction syndrome (CCDS).

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