Canine ACTH antibody and antigen (recombinant protein)

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-CAN-ACTH-Ag01	Recombinant Canine ACTH protein	3090
GMP-CAN-ACTH-Ab01	Anti-Canine ACTH mouse monoclonal antibody (mAb)	1953
GMP-CAN-ACTH-Ab02	Anti-Canine ACTH mouse monoclonal antibody (mAb)	1953
GMP-CAN-ACTH-Ab03	Anti-Canine ACTH human monoclonal antibody (mAb)	1953
GMP-CAN-ACTH-Ab04	Anti-Canine ACTH human monoclonal antibody (mAb)	1953

Size： 1mg | 10mg | 100mg

Product Description

Cat No. of Products	GMP-CAN-ACTH-Ag01
Product Name	Recombinant Canine ACTH protein
Target/Biomarker	Canine adrenocorticotropic hormone (ACTH)
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Canine adrenocorticotropic hormone antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in ACTH level test of animal Dog/Canine with pituitary or adrenal malfunction, pituitary tumor, adrenal tumor, lung tumor.
Tag	His
Products description	Recombinant Canine ACTH protein was expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-CAN-ACTH-Ab01, GMP-CAN-ACTH-Ab02
Product Name	Anti-Canine ACTH mouse monoclonal antibody (mAb)
Target/Biomarker	Canine adrenocorticotropic hormone (ACTH)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Canine adrenocorticotropic hormone antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-ACTH antibodies in ACTH level test of animal Dog/Canine with pituitary or adrenal malfunction, pituitary tumor, adrenal tumor, lung tumor.
Tag	mFc
Products description	Anti-Canine ACTH mouse monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-ACTH antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-CAN-ACTH-Ab03, GMP-CAN-ACTH-Ab04
Product Name	Anti-Canine ACTH human monoclonal antibody (mAb)
Target/Biomarker	Canine adrenocorticotropic hormone (ACTH)
Expression platform	CHO
Isotypes	Human IgG1
Bioactivity validation	Recombinant Canine adrenocorticotropic hormone antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-ACTH antibodies in ACTH level test of animal Dog/Canine with pituitary or adrenal malfunction, pituitary tumor, adrenal tumor, lung tumor.
Tag	hFc
Products description	Anti-Canine ACTH human monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-ACTH antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Target/Biomarker information

Adrenocorticotropic Hormone (ACTH) is a pivotal player in the endocrine system of dogs, orchestrating the body's response to stressors and maintaining hormonal balance. Structurally, ACTH is a 39-amino acid peptide hormone produced and secreted by the anterior pituitary gland. It belongs to the family of melanocortins, a group of hormones with diverse physiological functions. The primary role of ACTH lies in its regulation of the adrenal glands, specifically the adrenal cortex. In response to stress or changes in the internal environment, the hypothalamus releases corticotropin-releasing hormone (CRH). CRH, in turn, triggers the secretion of ACTH from the anterior pituitary gland. ACTH then enters the bloodstream and travels to the adrenal cortex. In the adrenal cortex, ACTH binds to specific receptors on the surface of adrenal cells, setting in motion a series of intracellular events. These events lead to the synthesis and release of cortisol, a corticosteroid hormone with far-reaching effects on the body. Cortisol, often referred to as the "stress hormone," plays a pivotal role in metabolic regulation, immune function, and the body's response to various stressors. It helps the body adapt to stressful situations by increasing blood glucose levels, suppressing the immune system, and modulating inflammation. Cortisol also influences other physiological processes, including protein and fat metabolism, electrolyte balance, and cardiovascular function.

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