Canine Aβ40 antibody and antigen (recombinant protein)

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-CAN-AB40-Ag01	Recombinant Canine Aβ40 protein	3090
GMP-CAN-AB40-Ab01	Anti-Canine Aβ40 mouse monoclonal antibody (mAb)	1953
GMP-CAN-AB40-Ab02	Anti-Canine Aβ40 mouse monoclonal antibody (mAb)	1953
GMP-CAN-AB40-Ab03	Anti-Canine Aβ40 human monoclonal antibody (mAb)	1953
GMP-CAN-AB40-Ab04	Anti-Canine Aβ40 human monoclonal antibody (mAb)	1953

Size： 1mg | 10mg | 100mg

Product Description

Cat No. of Products	GMP-CAN-AB40-Ag01
Product Name	Recombinant Canine Aβ40 protein
Target/Biomarker	Canine beta-amyloid 40 (AIV-A H7N7 subtype)
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Canine beta-amyloid 40 antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in AIV-A H7N7 subtype level test of animal Dog/Canine with Alzheimer Disease(AD).
Tag	His
Products description	Recombinant Canine Aβ40 protein was expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-CAN-AB40-Ab01, GMP-CAN-AB40-Ab02
Product Name	Anti-Canine Aβ40 mouse monoclonal antibody (mAb)
Target/Biomarker	Canine beta-amyloid 40 (AIV-A H7N7 subtype)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Canine beta-amyloid 40 antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-AIV-A H7N7 subtype antibodies in AIV-A H7N7 subtype level test of animal Dog/Canine with Alzheimer Disease(AD).
Tag	mFc
Products description	Anti-Canine Aβ40 mouse monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-AIV-A H7N7 subtype antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-CAN-AB40-Ab03, GMP-CAN-AB40-Ab04
Product Name	Anti-Canine Aβ40 human monoclonal antibody (mAb)
Target/Biomarker	Canine beta-amyloid 40 (AIV-A H7N7 subtype)
Expression platform	CHO
Isotypes	Human IgG1
Bioactivity validation	Recombinant Canine beta-amyloid 40 antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-AIV-A H7N7 subtype antibodies in AIV-A H7N7 subtype level test of animal Dog/Canine with Alzheimer Disease(AD).
Tag	hFc
Products description	Anti-Canine Aβ40 human monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-AIV-A H7N7 subtype antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Target/Biomarker information

Canine Amyloid-beta 40 (Aβ40) stands as a pivotal molecule in canine neuroscience, assuming a central role in our understanding of neurodegenerative conditions affecting our beloved canine companions. Comprising 40 amino acids, Aβ40 is a fragment of the amyloid precursor protein (APP) and represents a critical component in the formation of amyloid plaques within the canine brain. These plaques, predominantly composed of Aβ40, are emblematic of cognitive decline in dogs, most notably in cases of canine cognitive dysfunction syndrome (CCDS). The genesis of Aβ40 involves proteolytic cleavage of APP, a process mediated by β-secretase and γ-secretase enzymes. In dogs afflicted by CCDS, an imbalance in Aβ40 metabolism and clearance results in its aggregation, leading to the accumulation of amyloid plaques. These plaques disrupt normal neural function, contributing substantially to the cognitive deficits and memory impairments observed in affected dogs. The implications of Aβ40 aggregation transcend cognitive deficits. Aβ40 aggregates can trigger neuroinflammation, oxidative stress, and synaptic dysfunction, all of which collectively contribute to the progressive neurological decline seen in dogs suffering from CCDS.

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