Canine A1M antibody and antigen (recombinant protein)

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-CAN-A1M-Ag01	Recombinant Canine A1M protein	3090
GMP-CAN-A1M-Ab01	Anti-Canine A1M mouse monoclonal antibody (mAb)	1953
GMP-CAN-A1M-Ab02	Anti-Canine A1M mouse monoclonal antibody (mAb)	1953
GMP-CAN-A1M-Ab03	Anti-Canine A1M human monoclonal antibody (mAb)	1953
GMP-CAN-A1M-Ab04	Anti-Canine A1M human monoclonal antibody (mAb)	1953

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Product Description

Cat No. of Products	GMP-CAN-A1M-Ag01
Product Name	Recombinant Canine A1M protein
Target/Biomarker	Canine Alpha-1-Microglobulin (A1M)
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Canine Alpha-1-Microglobulin antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in A1M level test of animal Dog/Canine with Proteinuria, preeclampsia,.
Tag	His
Products description	Recombinant Canine A1M protein was expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-CAN-A1M-Ab01, GMP-CAN-A1M-Ab02
Product Name	Anti-Canine A1M mouse monoclonal antibody (mAb)
Target/Biomarker	Canine Alpha-1-Microglobulin (A1M)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Canine Alpha-1-Microglobulin antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-A1M antibodies in A1M level test of animal Dog/Canine with Proteinuria, preeclampsia,.
Tag	mFc
Products description	Anti-Canine A1M mouse monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-A1M antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-CAN-A1M-Ab03, GMP-CAN-A1M-Ab04
Product Name	Anti-Canine A1M human monoclonal antibody (mAb)
Target/Biomarker	Canine Alpha-1-Microglobulin (A1M)
Expression platform	CHO
Isotypes	Human IgG1
Bioactivity validation	Recombinant Canine Alpha-1-Microglobulin antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-A1M antibodies in A1M level test of animal Dog/Canine with Proteinuria, preeclampsia,.
Tag	hFc
Products description	Anti-Canine A1M human monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-A1M antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Target/Biomarker information

Dog/Canine Alpha-1-Microglobulin (A1M) emerges as an indispensable guardian of canine health, offering multifaceted protection against oxidative damage and tissue injury. Structurally, A1M is a glycoprotein characterized by its low molecular weight and intricate polypeptide chain, consisting of approximately 183 amino acids. Its primary site of synthesis is the liver, where it is meticulously crafted and subsequently released into the circulatory system, ready to execute its vital functions. At the heart of A1M's significance lies its role as a stalwart defender against oxidative stress. This biomarker stands poised to intercept and neutralize free radicals, highly reactive molecules that, when left unchecked, can inflict extensive damage to cellular structures, including proteins, lipids, and DNA. By harnessing its antioxidant prowess, A1M shields canine cells from the ravages of oxidative stress, ensuring the preservation of cellular integrity. Beyond its antioxidant functions, A1M exhibits a remarkable capacity to counteract tissue injury. It achieves this by forming complexes with substances generated during tissue damage, thereby preventing their toxic effects. A1M's multifunctional nature extends to its ability to bind heme, a molecule released during the breakdown of hemoglobin. By sequestering heme, A1M curtails its potential for tissue harm, offering a crucial line of defense in situations like hemolysis or hemorrhage.

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