Bovine proBNP antibody and antigen (recombinant protein)

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-BOV-proBNP-Ag01	Recombinant Bovine proBNP protein	3090
GMP-BOV-proBNP-Ab01	Anti-Bovine proBNP mouse monoclonal antibody (mAb)	1953
GMP-BOV-proBNP-Ab02	Anti-Bovine proBNP mouse monoclonal antibody (mAb)	1953
GMP-BOV-proBNP-Ab03	Anti-Bovine proBNP human monoclonal antibody (mAb)	1953
GMP-BOV-proBNP-Ab04	Anti-Bovine proBNP human monoclonal antibody (mAb)	1953

Size： 1mg | 10mg | 100mg

Product Description

Cat No. of Products	GMP-BOV-proBNP-Ag01
Product Name	Recombinant Bovine proBNP protein
Target/Biomarker	Bovine Pro B-Type Natriuretic Peptide (proBNP)
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Bovine Pro B-Type Natriuretic Peptide antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in proBNP level test of animal Bovines/Cattle with intrinsic cardiac dysfunction.
Tag	His
Products description	Recombinant Bovine proBNP protein was expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-BOV-proBNP-Ab01, GMP-BOV-proBNP-Ab02
Product Name	Anti-Bovine proBNP mouse monoclonal antibody (mAb)
Target/Biomarker	Bovine Pro B-Type Natriuretic Peptide (proBNP)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Bovine Pro B-Type Natriuretic Peptide antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-proBNP antibodies in proBNP level test of animal Bovines/Cattle with intrinsic cardiac dysfunction.
Tag	mFc
Products description	Anti-Bovine proBNP mouse monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-proBNP antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-BOV-proBNP-Ab03, GMP-BOV-proBNP-Ab04
Product Name	Anti-Bovine proBNP human monoclonal antibody (mAb)
Target/Biomarker	Bovine Pro B-Type Natriuretic Peptide (proBNP)
Expression platform	CHO
Isotypes	Human IgG1
Bioactivity validation	Recombinant Bovine Pro B-Type Natriuretic Peptide antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-proBNP antibodies in proBNP level test of animal Bovines/Cattle with intrinsic cardiac dysfunction.
Tag	hFc
Products description	Anti-Bovine proBNP human monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-proBNP antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Target/Biomarker information

N-terminal prohormone of brain natriuretic peptide (NT-proBNP) is a circulating biomarker that is derived from the precursor molecule proBNP, which is synthesized in the cardiac ventricles of animals, including bovines/cattle. ProBNP consists of a 108-amino acid polypeptide that is cleaved into two distinct fragments, N-terminal proBNP (NT-proBNP) and active brain natriuretic peptide (BNP). NT-proBNP is released into the bloodstream in response to cardiac stress or injury, as well as mechanical and neurohormonal stimuli. It is a marker of cardiac strain and dysfunction, reflecting increased wall tension in the ventricles. The concentration of NT-proBNP in the bloodstream reflects the degree of cardiac impairment, making it a valuable biomarker for monitoring cardiovascular health and predicting adverse events in bovines/cattle. NT-proBNP achieves its vasodilatory and natriuretic effects through the interaction of natriuretic peptide receptor A (NPRA) and NPRA-associated guanylate cyclase domains. The resulting increase in cyclic guanosine monophosphate (cGMP) leads to the relaxation of vascular smooth muscles and increased salt and water excretion. NT-proBNP has a relatively long half-life of approximately 1-2 hours, making it a useful diagnostic tool as it remains elevated for more extended periods than the active hormone BNP. It can be measured in serum or plasma using various immunoassays, including enzyme-linked immunosorbent assay (ELISA) and chemiluminescent immunoassay (CLIA). NT-proBNP levels are age and breed-specific, with healthy animals exhibiting lower levels than those affected by cardiovascular disease.

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